Disease: Acute lymphocytic leukemia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885
STAT1 P42224 signal transducer and activator of transcription 1 Nucleic acid binding 1.00 0.399 0.885
ISG20 Q96AZ6 interferon stimulated exonuclease gene 20 2.9E-03 0.414 0.846
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808
TYMS P04818 thymidylate synthetase Enzyme 0.72 0.425 0.846
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885
MCL1 Q07820 MCL1 apoptosis regulator, BCL2 family member Signaling 0.96 0.430 0.808
FOXO3 O43524 forkhead box O3 0.99 0.431 0.808
FOXO1 Q12778 forkhead box O1 1.00 0.433 0.846
LEPR P48357 leptin receptor Signaling 0.99 0.433 0.808
PTPRC P08575 protein tyrosine phosphatase receptor type C Enzyme 1.00 0.435 0.808
HFE Q30201 homeostatic iron regulator 2.6E-08 0.436 0.846
TFRC P02786 transferrin receptor Enzyme 7.0E-05 0.437 0.885