Disease: Leigh Syndrome due to Mitochondrial Complex IV Deficiency
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
COX15 Q7KZN9 cytochrome c oxidase assembly homolog COX15 1.1E-13 0.638 0.538
FOXRED1 Q96CU9 FAD dependent oxidoreductase domain containing 1 Enzyme 2.0E-16 0.633 0.462
NDUFA10 O95299 NADH:ubiquinone oxidoreductase subunit A10 Enzyme 6.2E-08 0.678 0.385
NDUFA12 Q9UI09 NADH:ubiquinone oxidoreductase subunit A12 7.4E-05 0.659 0.462
NDUFA2 O43678 NADH:ubiquinone oxidoreductase subunit A2 Enzyme 0.77 0.617 0.577
NDUFA9 Q16795 NADH:ubiquinone oxidoreductase subunit A9 Enzyme 4.8E-03 0.653 0.385
NDUFS1 P28331 NADH:ubiquinone oxidoreductase core subunit S1 Enzyme 6.6E-11 0.595 0.692
NDUFS3 O75489 NADH:ubiquinone oxidoreductase core subunit S3 5.8E-04 0.581 0.769
NDUFS4 O43181 NADH:ubiquinone oxidoreductase subunit S4 3.1E-04 0.587 0.808
NDUFS7 O75251 NADH:ubiquinone oxidoreductase core subunit S7 0.91 0.579 0.769
NDUFS8 O00217 NADH:ubiquinone oxidoreductase core subunit S8 Enzyme 0.17 0.636 0.538
NDUFV1 P49821 NADH:ubiquinone oxidoreductase core subunit V1 6.4E-11 0.617 0.538
NDUFV2 P19404 NADH:ubiquinone oxidoreductase core subunit V2 5.6E-03 0.610 0.500
PDHA1 P08559 pyruvate dehydrogenase E1 subunit alpha 1 0.99 0.581 0.538
PET100 P0DJ07 PET100 cytochrome c oxidase chaperone 3.6E-04 0.650 0.577
SDHA P31040 succinate dehydrogenase complex flavoprotein subunit A Enzyme 2.6E-10 0.517 0.731
SLC19A3 Q9BZV2 solute carrier family 19 member 3 Transporter 0.10 0.610 0.692
SURF1 Q15526 SURF1 cytochrome c oxidase assembly factor Enzyme 1.6E-13 0.578 0.654
TACO1 Q9BSH4 translational activator of cytochrome c oxidase I 1.5E-03 0.647 0.577