Disease: Familial Alzheimer Disease (FAD)
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885
ADAM10 O14672 ADAM metallopeptidase domain 10 1.00 0.489 0.846
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
BACE1 P56817 beta-secretase 1 Enzyme 0.88 0.559 0.769
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923
CLU P10909 clusterin 7.8E-05 0.426 0.885
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885
IDE P14735 insulin degrading enzyme Enzyme 6.6E-03 0.604 0.577
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962
IL6 P05231 interleukin 6 0.32 0.248 0.962
INS P01308 insulin 0.30 0.445 0.923
LAMC2 Q13753 laminin subunit gamma 2 Enzyme modulator 2.9E-12 0.389 0.923
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885
NEFL P07196 neurofilament light 0.488 0.769
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885
NRGN Q92686 neurogranin 0.48 0.608 0.615
PICALM Q13492 phosphatidylinositol binding clathrin assembly protein Transporter 1.00 0.592 0.538
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923