Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808
SF3B2 Q13435 splicing factor 3b subunit 2 1.00 0.780 0.308
IDH2 P48735 isocitrate dehydrogenase (NADP(+)) 2 0.88 0.434 0.808
CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 0.99 0.769 0.192
AXIN1 O15169 axin 1 0.41 0.559 0.577
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885
RXRA P19793 retinoid X receptor alpha Nuclear receptor 1.00 0.543 0.769
SF3B1 O75533 splicing factor 3b subunit 1 Nucleic acid binding 1.00 0.511 0.731
IGF2R P11717 insulin like growth factor 2 receptor Receptor 1.00 0.518 0.731
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962