|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
CONCLUSION: Although MTHFR C677T and A1298C are significantly associated with some types of congenital defects and adverse pregnancy outcomes, the impact of these polymorphisms is moderate.
|
30474229 |
2019 |
|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We evaluated five single-nucleotide polymorphisms (SNPs) in genes related to folic acid metabolism: methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), solute carrier family 19, member 1 (SLC19A1 G80A), methionine synthase (MTR A2576G), and methionine synthase reductase (MTRR A66G), as risk factors for CTDs including various types of malformation, in a total of 193 mothers with CTD-affected offspring and 234 healthy controls in a Chinese population.
|
30165839 |
2018 |
|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the possible relationship between Factor V (FV) 1691G>A, Factor II (FII) 20210G>A mutations and methylenetetrahydrofolate reductase (MTHFR) 677C>T; 1298A>C and Factor XIII (FXIII) 103G>T gene polymorphisms and the occurrence of IVH in 100 infants born from 24 + 0 to 32 + 0 weeks of gestation, born from singleton pregnancy, before 32 + 0 weeks of gestation, exposed to antenatal steroid therapy, and without congenital abnormalities.
|
28578513 |
2017 |
|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The minor allelic frequencies of the MTHFD1 1958G>A and MTHFR 1298A>C in our populations were similar to those reported from Southeast Asian population, suggesting a possible explanation for the prevalence of this malformation in these regions.
|
28398708 |
2017 |
|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In the group of CA of the cardiovascular system, we observed an association of MTHFR A1298C with decreased risk and an association of MTR A2756G with increased risk of CA.
|
22855024 |
2012 |
|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with complex congenital malformations.
|
18452180 |
2008 |
|
rs397507444
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We studied whether two polymorphisms in the MTHFR gene (677C-->T and 1298A-->C) are associated with pregnancy complications, adverse outcomes, and birth defects.
|
15210385 |
2004 |