|
rs7688285
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of rs7688285 allelic variation coding for GLRB with fear reactivity and exposure-based therapy in patients with panic disorder and agoraphobia.
|
31444036 |
2019 |
|
rs7688285
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We followed up on this finding in a larger dimensional ACQ sample (N=2547) and in independent samples with a dichotomous AG phenotype based on the Symptoms Checklist (SCL-90; N=3845) and a case-control sample with the categorical phenotype PD/AG (N<sub>combined</sub> =1012) obtaining highly significant P-values also for GLRB single-nucleotide variants rs17035816 (P=3.8 × 10<sup>-4</sup>) and rs7688285 (P=7.6 × 10<sup>-5</sup>).
|
28167838 |
2017 |
|
rs2271933
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The HCRTR1 rs2271933 T allele was associated with PD/AG in both samples independently, and in their meta-analysis (p = 4.2 × 10<sup>-7</sup>), particularly in the female subsample (p = 9.8 × 10<sup>-9</sup>).
|
30718541 |
2019 |
|
rs17035816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We followed up on this finding in a larger dimensional ACQ sample (N=2547) and in independent samples with a dichotomous AG phenotype based on the Symptoms Checklist (SCL-90; N=3845) and a case-control sample with the categorical phenotype PD/AG (N<sub>combined</sub> =1012) obtaining highly significant P-values also for GLRB single-nucleotide variants rs17035816 (P=3.8 × 10<sup>-4</sup>) and rs7688285 (P=7.6 × 10<sup>-5</sup>).
|
28167838 |
2017 |
|
rs6295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.
|
28096880 |
2017 |
|
rs17303244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results showed that rs17303244 was associated with the fear component of internalizing (i.e., defined by symptoms of panic, agoraphobia, specific phobia, and obsessive-compulsive disorder) at a level of significance that withstood correction for gene-wide multiple testing.
|
24007783 |
2013 |
|
rs324981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional NPSR A/T (Asn¹⁰⁷Ile) variant (rs324981) was investigated for association with (1) panic disorder with and without agoraphobia in two large, independent case-control studies, (2) dimensional anxiety traits, (3) autonomic arousal level during a behavioral avoidance test and (4) brain activation correlates of anxiety-related emotional processing in panic disorder.
|
20603625 |
2011 |
|
rs5751876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We were indeed able to replicate rs5751876 as risk factor for PD, particularly PD with agoraphobia.
|
20334879 |
2010 |
|
rs11724320
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A synonymous (Gly-426-Gly) NPY Y5 coding variant (rs11946004) as well as haplotypes including rs11946004 and an intronic NPY Y5 variant (rs11724320) were significantly associated with panic disorder (P = 0.027), with the effect originating from the subgroup of female patients (P = 0.030), particularly with concurrent agoraphobia (P = 0.002-0.019).
|
17948870 |
2008 |
|
rs11946004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A synonymous (Gly-426-Gly) NPY Y5 coding variant (rs11946004) as well as haplotypes including rs11946004 and an intronic NPY Y5 variant (rs11724320) were significantly associated with panic disorder (P = 0.027), with the effect originating from the subgroup of female patients (P = 0.030), particularly with concurrent agoraphobia (P = 0.002-0.019).
|
17948870 |
2008 |
|
rs1718119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found, however, a prominent association between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale.
|
17197037 |
2007 |
|
rs3817190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found, however, a prominent association between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale.
|
17197037 |
2007 |