rs1801028
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We analyzed the DRD2 311Ser/Cys polymorphism in 312 German alcoholics and 131 ethnically matched controls to investigate the association of genetic DRD2 variants with alcoholism or clinical characteristics of homogeneous subgroups of alcoholics.
|
8727249 |
1996 |
rs1801028
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Therefore, we were able to provide a critical test of the D2 hypothesis of vulnerability to alcoholism by evaluating Ser311Cys and also the intron-2 STR and Taq1A markers at this locus in a total of 459 subjects, including 373 sib pairs, from large families.
|
9259374 |
1997 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRM gene contributes a major effect to the pathogenesis of alcohol dependence.
|
9884158 |
1998 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In the Southwestern American Indian tribe, significant sib pair linkage of antisocial alcoholism</span> to HTR1B G861C (P=.01) was again observed, and there was also significant linkage to D6S284 (P=.01).
|
9819067 |
1998 |
rs1801028
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genotyping of Ser311Cys, the DRD2 intron 2 STR, and the Taq1A marker in 459 subjects, including 373 sib-pairs and 15 Cys311/Cys311 homozygous individuals, revealed no association to alcoholism, substance use disorders, or schizophrenia.
|
9650635 |
1998 |
rs6318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This finding suggests that 5-HT2C receptors are involved in the regulation of norepinephrine turnover in humans; however, HTR2C Cys23Ser does not appear to contribute to the risk of alcoholism, or its contribution to this complex and heterogenous disorder is too small to be detected by a sample of this size and structure.
|
10494451 |
1999 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy.
|
11104852 |
2000 |
rs6318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
5-HT2C Cys23Ser allele frequencies and genotypes did not differ among patients with alcohol dependence, panic disorder, generalized anxiety disorder, narcolepsy and normal healthy volunteers.
|
10994642 |
2000 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism of the mu-opioid receptor gene (OPRM1) as a particular vulnerability factor for heroin and alcohol dependence.
|
11424981 |
2001 |
rs16139
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We have screened 200 Japanese workers and 105 Japanese patients with alcoholism for the mutation in the signal peptide of pre-pro-neuropeptide Y resulting in a substitution of proline for leucine at position 7.
|
11409703 |
2001 |
rs6313
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There was no association between the 5-HT2A receptor polymorphism (T102C</span>), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients.
|
11444684 |
2001 |
rs1805002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CCK(B) receptor polymorphism Val125Ile was also not associated with alcoholism and the Ile125 allele frequencies were 0.05 in controls vs. 0.06 in alcohol-dependent subjects.
|
11368834 |
2001 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
There exists preliminary evidence for association of G861C with i) antisocial alcoholism in the Finnish; ii) alcoholism in the presence of inactive aldehyde dehydrogenase 2 in the Japanese; iii) a history of suicide attempts in European-American personality disorder patients; and iv) minimum lifetime body mass index in Canadian bulimia nervosa patients.
|
12437478 |
2002 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Consequently, genes encoding serotonin (5-HT) receptors are candidates for genetic studies of both disorders. found evidence for linkage of antisocial alcoholism to HTR1B (the locus encoding the 5-HT1B receptor) in both Finns and Southwestern American Indians, and of allelic association of a G861C polymorphism at that locus with antisocial alcoholism in Finns.
|
11751038 |
2002 |
rs16139
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States.
|
12215082 |
2002 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No significant association of the genotype or allele frequencies of the h5-HTR(1B) G861C locus was observed with diagnoses of alcoholism, bipolar disorder, schizophrenia or a history of a suicide attempt.
|
12496953 |
2003 |
rs16139
|
|
|
0.040 |
GeneticVariation |
BEFREE |
NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations.
|
12544000 |
2003 |
rs6318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In our sample, the functional relevant 5-HTT promoter and the 5-HT2c receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
|
14574222 |
2003 |
rs780312650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of this functional variant in 463 Southwestern Native Americans revealed no significant association between the DUSP8 C712T (Ala193Val) polymorphism and alcohol dependence (odds ratio = 1.48 95% CI 0.6-3.92).
|
13129832 |
2003 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His.
|
15048643 |
2004 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that having one or two copies of the A118G allele is common among Koreans and may be an important genetic factor in the etiology of alcohol dependence and the frequency of alcohol consumption.
|
15252283 |
2004 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
rs4680
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
rs324650
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome.
|
15229186 |
2004 |
rs2061174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome.
|
15229186 |
2004 |