Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801028
rs1801028
0.030 GeneticVariation BEFREE We analyzed the DRD2 311Ser/Cys polymorphism in 312 German alcoholics and 131 ethnically matched controls to investigate the association of genetic DRD2 variants with alcoholism or clinical characteristics of homogeneous subgroups of alcoholics. 8727249

1996

dbSNP: rs1801028
rs1801028
0.030 GeneticVariation BEFREE Therefore, we were able to provide a critical test of the D2 hypothesis of vulnerability to alcoholism by evaluating Ser311Cys and also the intron-2 STR and Taq1A markers at this locus in a total of 459 subjects, including 373 sib pairs, from large families. 9259374

1997

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRM gene contributes a major effect to the pathogenesis of alcohol dependence. 9884158

1998

dbSNP: rs6296
rs6296
0.080 GeneticVariation BEFREE In the Southwestern American Indian tribe, significant sib pair linkage of antisocial alcoholism</span> to HTR1B G861C (P=.01) was again observed, and there was also significant linkage to D6S284 (P=.01). 9819067

1998

dbSNP: rs1801028
rs1801028
0.030 GeneticVariation BEFREE Genotyping of Ser311Cys, the DRD2 intron 2 STR, and the Taq1A marker in 459 subjects, including 373 sib-pairs and 15 Cys311/Cys311 homozygous individuals, revealed no association to alcoholism, substance use disorders, or schizophrenia. 9650635

1998

dbSNP: rs6318
rs6318
0.030 GeneticVariation BEFREE This finding suggests that 5-HT2C receptors are involved in the regulation of norepinephrine turnover in humans; however, HTR2C Cys23Ser does not appear to contribute to the risk of alcoholism, or its contribution to this complex and heterogenous disorder is too small to be detected by a sample of this size and structure. 10494451

1999

dbSNP: rs6296
rs6296
0.080 GeneticVariation BEFREE The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. 11104852

2000

dbSNP: rs6318
rs6318
0.030 GeneticVariation BEFREE 5-HT2C Cys23Ser allele frequencies and genotypes did not differ among patients with alcohol dependence, panic disorder, generalized anxiety disorder, narcolepsy and normal healthy volunteers. 10994642

2000

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism of the mu-opioid receptor gene (OPRM1) as a particular vulnerability factor for heroin and alcohol dependence. 11424981

2001

dbSNP: rs16139
rs16139
0.040 GeneticVariation BEFREE We have screened 200 Japanese workers and 105 Japanese patients with alcoholism for the mutation in the signal peptide of pre-pro-neuropeptide Y resulting in a substitution of proline for leucine at position 7. 11409703

2001

dbSNP: rs6313
rs6313
0.040 GeneticVariation BEFREE There was no association between the 5-HT2A receptor polymorphism (T102C</span>), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients. 11444684

2001

dbSNP: rs1805002
rs1805002
0.010 GeneticVariation BEFREE The CCK(B) receptor polymorphism Val125Ile was also not associated with alcoholism and the Ile125 allele frequencies were 0.05 in controls vs. 0.06 in alcohol-dependent subjects. 11368834

2001

dbSNP: rs6296
rs6296
0.080 GeneticVariation BEFREE There exists preliminary evidence for association of G861C with i) antisocial alcoholism in the Finnish; ii) alcoholism in the presence of inactive aldehyde dehydrogenase 2 in the Japanese; iii) a history of suicide attempts in European-American personality disorder patients; and iv) minimum lifetime body mass index in Canadian bulimia nervosa patients. 12437478

2002

dbSNP: rs6296
rs6296
0.080 GeneticVariation BEFREE Consequently, genes encoding serotonin (5-HT) receptors are candidates for genetic studies of both disorders. found evidence for linkage of antisocial alcoholism to HTR1B (the locus encoding the 5-HT1B receptor) in both Finns and Southwestern American Indians, and of allelic association of a G861C polymorphism at that locus with antisocial alcoholism in Finns. 11751038

2002

dbSNP: rs16139
rs16139
0.040 GeneticVariation BEFREE A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. 12215082

2002

dbSNP: rs6296
rs6296
0.080 GeneticVariation BEFREE No significant association of the genotype or allele frequencies of the h5-HTR(1B) G861C locus was observed with diagnoses of alcoholism, bipolar disorder, schizophrenia or a history of a suicide attempt. 12496953

2003

dbSNP: rs16139
rs16139
0.040 GeneticVariation BEFREE NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. 12544000

2003

dbSNP: rs6318
rs6318
0.030 GeneticVariation BEFREE In our sample, the functional relevant 5-HTT promoter and the 5-HT2c receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence. 14574222

2003

dbSNP: rs780312650
rs780312650
0.010 GeneticVariation BEFREE Genotyping of this functional variant in 463 Southwestern Native Americans revealed no significant association between the DUSP8 C712T (Ala193Val) polymorphism and alcohol dependence (odds ratio = 1.48 95% CI 0.6-3.92). 13129832

2003

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. 15048643

2004

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE These results suggest that having one or two copies of the A118G allele is common among Koreans and may be an important genetic factor in the etiology of alcohol dependence and the frequency of alcohol consumption. 15252283

2004

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. 15584875

2004

dbSNP: rs4680
rs4680
0.070 GeneticVariation BEFREE Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. 15584875

2004

dbSNP: rs324650
rs324650
0.020 GeneticVariation BEFREE Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome. 15229186

2004

dbSNP: rs2061174
rs2061174
0.010 GeneticVariation BEFREE Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome. 15229186

2004