Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASDB In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35). 23456092

2013

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. 21968928

2012

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Individuals heterozygous or homozygous for the lys (A or *2) allele at the single nucleotide polymorphism (SNP) glu504lys (rs671) of ALDH2 have greatly reduced ability to metabolize acetaldehyde, which greatly decreases their risk for alcohol dependence (AD). 22102315

2012

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. 19710201

2010

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population. 20180859

2010

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Carrying the alcohol dehydrogenase 1B 48His allele (rs1229984 or ADH1B*2) could decrease the risk of alcoholism, but with persistent drinking may confer a greater risk of CLDs. 20219057

2010

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population. 20180859

2010

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism. 16086315

2005

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Data presented show that antialcohol drugs that inhibit Aldh2 gene expression can be generated endogenously in liver cells infected by an adenoviral vector carrying an antisense-coding gene, thus mimicking the high-acetaldehyde phenotype that exists in humans carrying the Glu487Lys mutation who are protected against alcoholism. 16131845

2005

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. 15048643

2004

dbSNP: rs1789891
rs1789891
0.820 GeneticVariation BEFREE Recent genome-wide systematic searches found associations between a single nucleotide polymorphism (rs1789891, risk allele: A, protective allele: C) in the alcohol dehydrogenase gene cluster and the risk of alcohol dependence. 29058369

2019

dbSNP: rs1789891
rs1789891
A 0.820 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907

2017

dbSNP: rs1789891
rs1789891
0.820 GeneticVariation BEFREE The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders. 26013422

2015

dbSNP: rs1789891
rs1789891
0.820 GeneticVariation GWASCAT Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012

dbSNP: rs1789891
rs1789891
0.820 GeneticVariation GWASDB Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012

dbSNP: rs750338
rs750338
0.810 GeneticVariation BEFREE The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively). 21703634

2011

dbSNP: rs750338
rs750338
C 0.810 GeneticVariation GWASDB The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively). 21703634

2011

dbSNP: rs750338
rs750338
C 0.810 GeneticVariation GWASCAT The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively). 21703634

2011

dbSNP: rs1000579
rs1000579
G 0.800 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907

2017

dbSNP: rs896543
rs896543
G 0.800 GeneticVariation GWASCAT Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. 24962325

2014

dbSNP: rs4478858
rs4478858
G 0.800 GeneticVariation GWASCAT NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. 23455491

2013

dbSNP: rs4478858
rs4478858
G 0.800 GeneticVariation GWASDB NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. 23455491

2013

dbSNP: rs896543
rs896543
0.800 GeneticVariation GWASDB A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. 23089632

2013

dbSNP: rs1000579
rs1000579
0.800 GeneticVariation GWASCAT Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012

dbSNP: rs1000579
rs1000579
0.800 GeneticVariation GWASDB Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012