Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1229984
rs1229984
C 0.900 GeneticVariation GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813

2019

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASCAT In the trans-ancestral meta-analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome-wide significant: rs61826952 (chromosome 1, DSM-IV AD, P = 8.42E-11); rs7597960 (chromosome 2, Time spent drinking, P = 1.22E-08). 31090166

2019

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE The inclusion of rs1229984 attenuated the effects of the alcohol consumption PRS, particularly for DSM4AD and DSM5AUDSX, but the PRS continued to exert an independent effect for all 5 alcohol measures (Δmarginal R<sup>2</sup> after controlling for ADH1B = 0.14 to 1.22%). 30994927

2019

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In the EA GWAS, three loci were genome-wide significant: rs1229984 in ADH1B for AD criterion count (P = 4.16E-11) and Desire to cut drinking (P = 1.21E-11); rs188227250 (chromosome 8, Drinking more than intended, P = 6.72E-09); rs1912461 (chromosome 15, Time spent drinking, P = 1.77E-08). 31090166

2019

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Our findings demonstrate that these variants, which were highly linked with ALDH2 rs671 and ADH1B rs1229984, were significant modulators for AD in our Han Chinese cohort. 31591379

2019

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Our findings demonstrate that these variants, which were highly linked with ALDH2 rs671 and ADH1B rs1229984, were significant modulators for AD in our Han Chinese cohort. 31591379

2019

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454

2018

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver. 29063269

2018

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454

2018

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver. 29063269

2018

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure. 27742538

2017

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. 28728635

2017

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In a genome-wide association study (GWAS), we identified highly significant associations between two population-specific functional variants in the alcohol dehydrogenase 1B gene (ADH1B) and AD in African-Americans (AAs; rs2066702) and European-Americans (EAs; rs1229984). 25828809

2016

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. 27172571

2016

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In conclusion, the rare ADH1B rs1229984 mutation provides significant protection against ADS in this British and Irish population; other variants in the ADH gene cluster also alter ADS risk, although the strong linkage disequilibrium between SNPs at this location precluded clear identification of the variant(s) driving the associations. 24735490

2015

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample. 25372623

2015

dbSNP: rs1229984
rs1229984
C 0.900 GeneticVariation GWASCAT Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. 24166409

2014

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism. 23969552

2014

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively. 25410943

2014

dbSNP: rs671
rs671
0.900 GeneticVariation GWASCAT When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks. 24277619

2014

dbSNP: rs671
rs671
0.900 GeneticVariation GWASDB When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks. 24277619

2014

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism. 23969552

2014

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks. 24277619

2014

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASCAT In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35). 23456092

2013

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASDB In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35). 23456092

2013