Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals. 20697030

2010

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Similarly, we identified that the minor allele variant of rs11136000 significantly decrease AD risk in Caucasian ethnicity using the allele, dominant and recessive model. 30038359

2018

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively). 21726919

2011

dbSNP: rs11136000
rs11136000
CLU
C 0.900 GeneticVariation GWASCAT Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 19734903

2009

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation GWASDB Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 19734903

2009

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). 21422520

2011

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation GWASCAT These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902

2009

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Genome-wide association studies identify rs11136000 in the CLU gene, which codes for Apolipoprotein J/Clusterin, as a significant risk variant for Alzheimer's disease (AD). 25496871

2015

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT). 28316001

2017

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population. 23650005

2013

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE We identified a significant association between rs1</span>1136000 and AD with the allele model (P = 2.00 × 10(-4)) and the dominant model (P = 5.00 × 10(-3)). 23892938

2014

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. 22506010

2012

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in MTHFR (rs1801133), PICALM (3851719), CLU (rs11136000), and CR1 (rs6701713) are associated with AD. 25359311

2015

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). 24578178

2015

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU). 21397462

2011

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Plasma clusterin levels and the rs11136000 genotype in individuals with mild cognitive impairment and Alzheimer's disease. 24117116

2013

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54). 28558900

2017

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD. 26899953

2016

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE We examined the effect of the novel Alzheimer's disease (AD) risk variant rs11136000 single nucleotide polymorphism in the clusterin gene (CLU) on longitudinal changes in resting state regional cerebral blood flow (rCBF) during normal aging and investigated its influence on cognitive decline in presymptomatic stages of disease progression. 22795969

2013

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients. 28631188

2018

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population. 22296908

2011

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation GWASDB These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902

2009

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE The significant association between rs11136000 and AD in the pooled population was found under all the models. 29396813

2018

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902

2009