Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6438552
rs6438552
0.020 GeneticVariation BEFREE GSK3β rs6438552 C>T polymorphism was correlated with increased the risk of developing AD only in Australian populations. 25351705

2015

dbSNP: rs6438552
rs6438552
0.020 GeneticVariation BEFREE In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele. 23525328

2013

dbSNP: rs1189501362
rs1189501362
0.010 GeneticVariation BEFREE These findings indicate that the major sites of tau phosphorylation, and the expression of kinases involved in tau phosphorylation are active in P</span>310L mutation as in AD and other tauopathies. 14757934

2003

dbSNP: rs334558
rs334558
0.050 GeneticVariation BEFREE Twelve GSK3B tag single-nucleotide polymorphisms (SNPs), together with the previously AD-associated rs334558, were analyzed in 583 AD patients and 673 controls. 25420549

2015

dbSNP: rs334558
rs334558
0.050 GeneticVariation BEFREE However, little is known about the potential role of the GSK-3β rs334558 polymorphism, which has been associated with amnestic mild cognitive impairment (aMCI), which is itself associated with a high risk of AD. 22785398

2012

dbSNP: rs334558
rs334558
0.050 GeneticVariation BEFREE Subjects carrying both the CDK5R1 (3'-UTR, rs735555) AA genotype and the GSK-3beta (-50, rs334558) CC genotype had a 12.5-fold decrease in AD risk (adjusted by age, sex and APOE status OR = 0.08, 95% CI = 0.01-0.76, P = 0.03), suggesting synergistic effects (epistasis) between both genes. 19154537

2009

dbSNP: rs334558
rs334558
0.050 GeneticVariation BEFREE The minor allele (T) of the promoter rs334558 within GSK3B was associated with an increased risk of LOAD (odds ratios/OR=1.381, P=0.006), T carriers may be easier to develop AD (P=0.002, power=0.92). 21443865

2011

dbSNP: rs334558
rs334558
0.050 GeneticVariation BEFREE Our findings suggest that there exists a significant association between GSK3β rs334558 T>C polymorphism and increased susceptibility of AD. 25351705

2015