rs6438552
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GSK3β rs6438552 C>T polymorphism was correlated with increased the risk of developing AD only in Australian populations.
|
25351705 |
2015 |
rs6438552
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.
|
23525328 |
2013 |
rs1189501362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that the major sites of tau phosphorylation, and the expression of kinases involved in tau phosphorylation are active in P</span>310L mutation as in AD and other tauopathies.
|
14757934 |
2003 |
rs334558
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Twelve GSK3B tag single-nucleotide polymorphisms (SNPs), together with the previously AD-associated rs334558, were analyzed in 583 AD patients and 673 controls.
|
25420549 |
2015 |
rs334558
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, little is known about the potential role of the GSK-3β rs334558 polymorphism, which has been associated with amnestic mild cognitive impairment (aMCI), which is itself associated with a high risk of AD.
|
22785398 |
2012 |
rs334558
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Subjects carrying both the CDK5R1 (3'-UTR, rs735555) AA genotype and the GSK-3beta (-50, rs334558) CC genotype had a 12.5-fold decrease in AD risk (adjusted by age, sex and APOE status OR = 0.08, 95% CI = 0.01-0.76, P = 0.03), suggesting synergistic effects (epistasis) between both genes.
|
19154537 |
2009 |
rs334558
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The minor allele (T) of the promoter rs334558 within GSK3B was associated with an increased risk of LOAD (odds ratios/OR=1.381, P=0.006), T carriers may be easier to develop AD (P=0.002, power=0.92).
|
21443865 |
2011 |
rs334558
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our findings suggest that there exists a significant association between GSK3β rs334558 T>C polymorphism and increased susceptibility of AD.
|
25351705 |
2015 |