|
rs2373115
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We believe that our findings provide important information regarding the rs2373115 variant and expression of nearby genes with respect to AD risk.
|
30088171 |
2018 |
|
rs3764650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The associations of rs3764650 with CSF Aβ<sub>1-42</sub>, t-tau and p-tau were analyzed in non-dementia AD, including preclinical and prodromal AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
|
30596067 |
2018 |
|
rs3764650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races.
|
29782324 |
2018 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship.
|
30039188 |
2018 |
|
rs3865444
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The <i>CD33</i> rs3865444 polymorphism could be a protective factor in AD.
|
29951491 |
2018 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs63750264
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this study, we utilized two animal models of AD to examine and characterize the AD-associated pathology: the Tg2576 Swedish APP (KM670/671NL) and TgCRND8 Swedish plus Indiana APP (KM670/671NL + V717F) lines.
|
30189875 |
2018 |
|
rs6656401
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three genotypes significantly associated with reduced AD risk relative to PART in the PENN (<i>N</i> = 377) and NACC (<i>N</i> = 1189) cohorts including <i>APOE ε</i>4, <i>APOE ε</i>2, and rs6656401 in the <i>CR1</i> gene.
|
30128317 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These data suggest that the AD-associated TREM2 R47H variant increases risk for AD by conferring a loss of TREM2 function and enhancing neuritic dystrophy around plaques.
|
29859094 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, supporting the hypothesis that TREM2 loss of function may exacerbate disease progression.
|
29599291 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We generated transgenic mice expressing human CV or R47H TREM2 and lacking endogenous TREM2 in the 5XFAD AD model.
|
29321225 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two DS cases had the AD-associated TREM2-R47H mutation, which manifested a morphologically extreme phenotype of megakaryocytes and erythrocytes in addition to impaired trafficking of TREM2 to the erythroid membrane.
|
29278889 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
|
29794134 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.
|
29902745 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.
|
29602048 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Mouse models accurately reproducing phenotypes observed in Alzheimer' disease patients carrying the R47H coding variant are required to understand the TREM2 related dysfunctions responsible for the enhanced risk for late onset Alzheimer's disease.
|
30185230 |
2018 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, the rare TREM2 variant (p.Arg47His), which was considered to be a risk factor for Alzheimer's disease in European descent populations, was not detected in our cohort.
|
29723869 |
2018 |
|
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
|
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, Kaplan-Meier survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele.
|
27023435 |
2017 |
|
rs2373115
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The fixed effect model analysis again showed no significant association between r</span>s2373115</span> and AD in these pooled populations.
|
28320126 |
2017 |
|
rs3764650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ABCA7 rs3764650 polymorphism was significantly associated with A</span>D risk (OR=1.21, 95% CI 1.16-1.26, P<0.00001; I2=5%).
|
29441941 |
2017 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD.
|
28073596 |
2017 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially.
|
27048444 |
2017 |