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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The current study examined potential association between single nucleotide polymorphisms (SNPs) of the BDNF gene (G11757 C, C270T, G196A, G-712A) and Alzheimer's disease-related depression (AD-D).
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21677379 |
2011 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The gene variants of the BDNF Val66Met polymorphism were significantly associated with the presence of psychotic symptoms in male, but not in female patients with AD.
|
21044653 |
2011 |
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rs6265
|
|
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0.100 |
GeneticVariation |
BEFREE |
To determine whether the BDNF Val66Met gene variant interacts with age to predict brain and cognitive measures in healthy volunteers across the adult lifespan in an intermediate phenotype pattern related to AD by examining (1) cortical thickness, (2) fractional anisotropy of white matter tracts (ie, white matter integrity), and (3) episodic memory performance.
|
21300947 |
2011 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although Val66Met polymorphisms were not associated with the cross-sectional diagnoses of MCI or AD, the presence of Met-BDNF allele was associated with a higher risk of disease-progression in patients with MCI (OR=3.0 CI(95%) [1.2-7.8], P=0.02).
|
20491609 |
2010 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men.
|
19504537 |
2010 |
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rs6265
|
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0.100 |
GeneticVariation |
BEFREE |
Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease.
|
19812463 |
2010 |
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rs6265
|
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|
0.100 |
GeneticVariation |
BEFREE |
Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.
|
20613678 |
2010 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent association studies have suggested that the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene could play a role in the development of AD.
|
18786162 |
2009 |
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rs6265
|
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|
0.100 |
GeneticVariation |
BEFREE |
A sample of AD subjects (N = 341) was genotyped for the BDNF polymorphisms: Val66Met, C270T, and G-712A.
|
19542613 |
2009 |
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rs6265
|
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|
0.100 |
GeneticVariation |
BEFREE |
Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression.
|
18179845 |
2009 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, several reports investigated the association between a single nucleotide polymorphism (Val66Met, rs6265) of the BDNF gene and AD but yielded ambiguous results.
|
17657167 |
2007 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To date, there have been several conflicting reports on the correlation between AD or PD and Val66Met or C270T polymorphism in the BDNF promoter region, although no data on this relationship have been published with respect to dementia with Lewy bodies (DLB).
|
16899999 |
2006 |
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rs6265
|
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|
0.100 |
GeneticVariation |
BEFREE |
We also tested BDNF Val66Met-C270T haplotypes for an interaction with the apolipoprotein E upsilon4 (APOE4) allele in AD.
|
16391475 |
2006 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
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rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD.
|
16627933 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction.
|
16565926 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046).
|
15375678 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese.
|
16054753 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD.
|
14730194 |
2004 |