rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The AA genotype of the aging-related single-nucleotide polymorphism (SNP) rs2075650 in TOMM40 has been associated with longevity, while the AG and GG genotypes are associated with an increased risk of Alzheimer's disease.
|
31318836 |
2020 |
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results support the consensus that the R47H variant is significantly associated with AD.
|
31513029 |
2020 |
rs2075650
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD).
|
29942042 |
2019 |
rs3764650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD.
|
31024289 |
2019 |
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
rs3865444
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
rs3865444
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
rs3865444
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results suggested that the two CD33 common variants (rs3826656 and rs3865444) influenced volumes and atrophy rates of AD-related brain regions in non-demented elders.
|
30883353 |
2019 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Education, sex, and the APOE-rs405509 variant are associated with Alzheimer's disease and cognitive performance.
|
31100889 |
2019 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested if the ε4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Cohort Study.
|
30293724 |
2019 |
rs405509
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among ε4/ε4 individuals, AD risk</span> increased substantially in a dose-dependent manner with the number of <i>APOE</i> promoter SNP rs405509 <i>T</i> alleles in EastAs <i>(TT</i>: OR (odds ratio) = 27.02, <i>p</i> = 8.80 × 10<sup>-94</sup>; <i>GT</i>: OR = 15.87, <i>p</i> = 2.62 × 10<sup>-9</sup>) and EuroAs (<i>TT</i>: OR = 18.13, <i>p</i> = 2.69 × 10<sup>-108</sup>; <i>GT</i>: OR = 12.63, <i>p</i> = 3.44 × 10<sup>-64</sup>), and rs405509-<i>T</i> homozygotes had a younger onset and more severe cortical atrophy than those with <i>G</i>-allele.
|
31426376 |
2019 |
rs63750264
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Dermal fibroblasts were obtained from a 55 year old male Сaucasian familial Alzheimer's disease (AD) patient carrying heterozygous V717I mutation in the APP gene.
|
30851551 |
2019 |
rs63750264
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this study, a novel mutation in APP gene, Val669Leu ("Seoul APP"), was reported in a Korean female patient with Alzheimer's disease.
|
31623876 |
2019 |
rs6656401
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
|
30805717 |
2019 |
rs6656401
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
rs6656401
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
rs744373
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown.
|
30992433 |
2019 |
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three variants in TREM2 (rs75932628 (R47H), rs2234255 (H157Y), and rs143332484 (R62H)) were significantly associated with AD risk, but the similar associations between rs104894002 (Q33X), rs2234253 (T96K), rs142232675 (D87N), rs2234256 (L211P), and AD were not proven.
|
30883352 |
2019 |
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Similarly, we identified that the minor allele variant of rs11136000 significantly decrease AD risk in Caucasian ethnicity using the allele, dominant and recessive model.
|
30038359 |
2018 |
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients.
|
28631188 |
2018 |
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The significant association between rs11136000 and AD in the pooled population was found under all the models.
|
29396813 |
2018 |
rs2075650
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
|
29107063 |
2018 |
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Minor variants: rs10524523-L, rs4420638-G, rs2075650-G were significantly overrepresented in AD.
|
30443289 |
2018 |