There is an association between the <i>SIRT2-C/T</i> genotype (rs10410544) (50.92%) and AD susceptibility in the <i>APOEε4</i>-negative population (<i>SIRT2-C/C</i>, 34.72%; <i>SIRT2-T/T</i> 14.36%).
A number of genetic variants have previously been identified and associated with the risk of Alzheimer's disease (AD), including rs10838725 in CELF1, rs28834970 in PTK2B, rs17125944 in FERMT2, and rs10410544 in SIRT2 based on genome-wide association studies.