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rs10524523
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0.100 |
GeneticVariation |
BEFREE |
To interrogate a poly-T variant (rs10524523, '523) in <i>TOMM40</i>, a gene adjacent to the <i>APOE</i> gene on chromosome 19, in older persons with <i>APOE</i> ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD).
|
28108637 |
2017 |
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rs10524523
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|
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0.100 |
GeneticVariation |
BEFREE |
Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline.
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28549947 |
2017 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The apolipoprotein E (<i>APOE</i>) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 (<i>TOMM40</i>) gene have been associated with the age of onset of AD.
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29124110 |
2017 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thirty-two presenilin 1 (PSEN1) mutation carriers with AD, 27 presenilin 2 (PSEN2) mutation carriers with AD, 59 participants with late-onset AD (LOAD), and 168 autopsied subjects from a community-based cohort were genotyped for TOMM40 intron 6 poly-T (rs10524523) length using short tandem repeat assays.
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23183136 |
2013 |
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rs10524523
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0.100 |
GeneticVariation |
BEFREE |
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
|
23333464 |
2013 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Because of the similarities between Alzheimer's disease and sporadic inclusion body myositis (s-IBM), and the importance of amyloid-β and mitochondrial changes in s-IBM, we investigated whether variation in poly-T repeat lengths in rs10524523 also influence susceptibility and age at onset in a cohort of 90 Caucasian s-IBM patients (55 males; age 69.1 ± 9.6).
|
24103330 |
2013 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease (AD) related phenotypes such as age of clinical onset.
|
24260406 |
2013 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation.
|
23792692 |
2013 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly.
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22359560 |
2012 |
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rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
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22869155 |
2012 |