To identify whether the variants in or near the <i>STARD6</i> and <i>ECHDC3</i> genes contribute to AD susceptibility, we carried out an association analysis of <i>STARD6</i> rs10164112 and <i>ECHDC3</i> rs7920721 in combination with the apolipoprotein E (<i>APOE</i>) ε4 allele in a case-control study (278 cases, 509 controls) in China.