Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs638405
rs638405
0.030 GeneticVariation BEFREE By exclusion of three studies that </span>did not conform to Hardy-Weinberg equilibrium (HWE), our data suggested rs638405 in BACE1 was a protective factor of AD. 26846559

2017

dbSNP: rs638405
rs638405
0.030 GeneticVariation BEFREE Our analysis demonstrated that GG genotype and G allele of BACE1 gene rs638405 probably increase the risk of AD. 26828303

2016

dbSNP: rs638405
rs638405
0.030 GeneticVariation BEFREE This study is an attempt to clarify whether the common SNP in exon 5 of BACE1 (rs638405, Val262) is associated with a risk for late-onset AD. 18182766

2008

dbSNP: rs759223338
rs759223338
0.020 GeneticVariation BEFREE However, studies investigating the association of single-nucleotide polymorphism (SNP) in exon 5 of BACE1 (rs638405, C786G, Val262) with AD are controversial. 26828303

2016

dbSNP: rs759223338
rs759223338
0.020 GeneticVariation BEFREE The allele frequencies of the 786C/G polymorphism were 0.622 for C and 0.378 for G in AD. 12535780

2003

dbSNP: rs1335506651
rs1335506651
0.010 GeneticVariation BEFREE The impact of celastrol on brain Abeta accumulation was tested in a transgenic mouse model of AD overexpressing the human APP695sw mutation and the presenilin-1 mutation M146L (Tg PS1/APPsw) by immunostaining and ELISAs. 20211007

2010

dbSNP: rs676134
rs676134
0.010 GeneticVariation BEFREE Evidence for an association with AD was observed with multi-marker haplotype analyses (P = 0.01), and with rs676134 when stratified for APOE genotype (P = 0.02), however adjusting for multiple testing negated the evidence for association of this variant with AD. chi(2) analysis of genotype and allele frequencies in cases versus controls for individual SNPs revealed no evidence for association (5% level). 18581272

2008