Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11218343
rs11218343
C 0.830 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation BEFREE We found two SNPs that had interactions with triglycerides on AD risk that reached a p-value < 0.05 (rs11218343 and APOEɛ4). 30412497

2018

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation BEFREE The results of meta-analysis in subgroups (Caucasian and Asian) and the whole showed that the minor allele (C allele) within rs11218343 played a protective effect on AD risk (OR (95 % CI), 0.77 (0.72-0.83), 0.85 (0.79-0.91), 0.81 (0.76-0.85), respectively). 26873856

2017

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation BEFREE Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures. 26732597

2017

dbSNP: rs11218343
rs11218343
T 0.830 GeneticVariation GWASDB Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737

2013

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013

dbSNP: rs11218343
rs11218343
0.830 GeneticVariation GWASCAT SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013

dbSNP: rs11218343
rs11218343
T 0.830 GeneticVariation GWASCAT Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737

2013

dbSNP: rs3781834
rs3781834
0.700 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013

dbSNP: rs377498269
rs377498269
0.700 GeneticVariation UNIPROT

dbSNP: rs747306346
rs747306346
0.700 GeneticVariation UNIPROT

dbSNP: rs2070045
rs2070045
0.050 GeneticVariation BEFREE The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD. 26611835

2016

dbSNP: rs2070045
rs2070045
0.050 GeneticVariation BEFREE In conclusion, we found that SORL1 SNP rs2070045-G allele was related to CSF-tau and hippocampal atrophy, 2 endophenotype markers of AD, suggesting that SORL1 may be implicated in the downstream pathology in AD. 25659857

2015

dbSNP: rs2070045
rs2070045
0.050 GeneticVariation BEFREE Single nucleotide polymorphisms of SORL1 reported in literature as being associated with AD were investigated in an Italian case-control data set, and their role as a risk factor of conversion to AD was studied in an independent sample of subjects diagnosed with mild cognitive impairment (MCI) at baseline. rs641120, rs2070045, and rs1010159 were genotyped in 734 subjects diagnosed with AD (n = 338) and MCI (n = 181) and in healthy controls (n = 215). 25881907

2015

dbSNP: rs2070045
rs2070045
0.050 GeneticVariation BEFREE Our studies identified a SORL1 haplotype in the 3' gene region consisting of single-nucleotide polymorphisms rs1699102 and rs2070045 that is associated with poor receptor expression in the brain of patients with Alzheimer disease. 22410445

2012

dbSNP: rs2070045
rs2070045
0.050 GeneticVariation BEFREE In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias. 19368828

2009

dbSNP: rs2282649
rs2282649
0.040 GeneticVariation BEFREE We aimed to investigate the association between polymorphisms in several cholesterol-related genes [APOA5 (rs662799), APOC1 (rs11568822), APOD (rs1568565), CH25H (rs13500), LDLR (rs5930), SORL1 (rs2282649)] and AD in a cohort of Turkish patients. 30684189

2019

dbSNP: rs1010159
rs1010159
0.040 GeneticVariation BEFREE Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations. 29036834

2018

dbSNP: rs641120
rs641120
0.040 GeneticVariation BEFREE Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations. 29036834

2018

dbSNP: rs2282649
rs2282649
0.040 GeneticVariation BEFREE The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD. 26611835

2016

dbSNP: rs3824968
rs3824968
0.040 GeneticVariation BEFREE Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan. 26996954

2016

dbSNP: rs1010159
rs1010159
0.040 GeneticVariation BEFREE In the MCI cohort, rs1010159 was associated with conversion to AD (HR = 1.56, p = 0.002). 25881907

2015

dbSNP: rs641120
rs641120
0.040 GeneticVariation BEFREE Our results confirmed the association between rs641120 and AD (p = 0.01). 25881907

2015