|
rs11218343
|
|
|
0.830 |
GeneticVariation |
BEFREE |
We found two SNPs that had interactions with triglycerides on AD risk that reached a p-value < 0.05 (rs11218343 and APOEɛ4).
|
30412497 |
2018 |
|
rs11218343
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The results of meta-analysis in subgroups (Caucasian and Asian) and the whole showed that the minor allele (C allele) within rs11218343 played a protective effect on AD risk (OR (95 % CI), 0.77 (0.72-0.83), 0.85 (0.79-0.91), 0.81 (0.76-0.85), respectively).
|
26873856 |
2017 |
|
rs11218343
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.
|
26732597 |
2017 |
|
rs2070045
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD.
|
26611835 |
2016 |
|
rs2070045
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, we found that SORL1 SNP rs2070045-G allele was related to CSF-tau and hippocampal atrophy, 2 endophenotype markers of AD, suggesting that SORL1 may be implicated in the downstream pathology in AD.
|
25659857 |
2015 |
|
rs2070045
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms of SORL1 reported in literature as being associated with AD were investigated in an Italian case-control data set, and their role as a risk factor of conversion to AD was studied in an independent sample of subjects diagnosed with mild cognitive impairment (MCI) at baseline. rs641120, rs2070045, and rs1010159 were genotyped in 734 subjects diagnosed with AD (n = 338) and MCI (n = 181) and in healthy controls (n = 215).
|
25881907 |
2015 |
|
rs2070045
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our studies identified a SORL1 haplotype in the 3' gene region consisting of single-nucleotide polymorphisms rs1699102 and rs2070045 that is associated with poor receptor expression in the brain of patients with Alzheimer disease.
|
22410445 |
2012 |
|
rs2070045
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.
|
19368828 |
2009 |
|
rs2282649
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We aimed to investigate the association between polymorphisms in several cholesterol-related genes [APOA5 (rs662799), APOC1 (rs11568822), APOD (rs1568565), CH25H (rs13500), LDLR (rs5930), SORL1 (rs2282649)] and AD in a cohort of Turkish patients.
|
30684189 |
2019 |
|
rs1010159
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations.
|
29036834 |
2018 |
|
rs641120
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations.
|
29036834 |
2018 |
|
rs2282649
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD.
|
26611835 |
2016 |
|
rs3824968
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.
|
26996954 |
2016 |
|
rs1010159
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the MCI cohort, rs1010159 was associated with conversion to AD (HR = 1.56, p = 0.002).
|
25881907 |
2015 |
|
rs641120
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results confirmed the association between rs641120 and AD (p = 0.01).
|
25881907 |
2015 |
|
rs641120
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.
|
23525328 |
2013 |
|
rs641120
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Ninety six outpatients with LOAD and 120 unrelated controls were genotyped for APOE and three SNPs at the 5' end of SORL1(intron 6): SNP 8 (rs668387); SNP 9 (rs68902); SNP 10 (rs641120).
|
23463934 |
2013 |
|
rs2282649
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Significant associations between CSF Aβ(1-42) levels and the SORL1 SNPs 23 (rs3824968) and 24 (rs2282649) were detected in the AD group.
|
21997402 |
2011 |
|
rs3824968
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Significant associations between CSF Aβ(1-42) levels and the SORL1 SNPs 23 (rs3824968) and 24 (rs2282649) were detected in the AD group.
|
21997402 |
2011 |
|
rs1010159
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We conducted a study of 7 single nucleotide polymorphisms (SNPs), rs668387, rs689021, rs641120, rs1699102, rs3824968, rs2282649, and rs1010159, in the SORL1 gene that were associated to AD in previous studies.
|
19584446 |
2009 |
|
rs1010159
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.
|
19368828 |
2009 |
|
rs2282649
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We conducted haloptype analysis involving two genetic clusters of SORL1 in AD and controls among Han Chinese. rs3824968 (SNP 23) was associated with an increased risk of AD, and there was a trend towards association for rs1699102 (SNP 22) and rs2282649 (SNP 24).
|
18063222 |
2009 |
|
rs3824968
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We conducted haloptype analysis involving two genetic clusters of SORL1 in AD and controls among Han Chinese. rs3824968 (SNP 23) was associated with an increased risk of AD, and there was a trend towards association for rs1699102 (SNP 22) and rs2282649 (SNP 24).
|
18063222 |
2009 |
|
rs3824968
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.
|
19368828 |
2009 |
|
rs668387
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The SNP of rs3851179 (PICALM), rs12285364 (SORL1), rs2070045 (SORL1), and rs2282649 (SORL1) was associated with an increased risk of AD, whereas SORL1 rs1010159, rs641120, rs668387, and rs689021 were associated with a decreased risk of AD.
|
26611835 |
2016 |