Gene: PON1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs662
rs662
PON1
0.030 GeneticVariation BEFREE PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival. 30903418

2019
dbSNP: rs662
rs662
PON1
0.030 GeneticVariation BEFREE This meta-analysis showed lack of associations between PON1 Q192R</span> and L55M polymorphisms and susceptibility to ALS in the European population. 25301263

2015
dbSNP: rs662
rs662
PON1
0.030 GeneticVariation BEFREE There was a trend toward increased paraoxonase activity in ALS compared with controls (mean control paraoxonase 701.9 +/- 469.7 U/L, mean ALS 792.5 +/- 574.1 U/L; p = 0.066 after correction) which correlated with increased frequency of the homozygous arginine (RR) variant of PON1(Q192R) (p = 0.004). 18347314

2008
dbSNP: rs854560
rs854560
PON1
0.020 GeneticVariation BEFREE This meta-analysis showed lack of associations between PON1 Q192R and L55M</span> polymorphisms and susceptibility to ALS in the European population. 25301263

2015
dbSNP: rs854560
rs854560
PON1
0.020 GeneticVariation BEFREE We found a significant interaction with population density for marker rs854560 (L55M) in ALS. 19104460

2009
dbSNP: rs2074351
rs2074351
PON1
0.010 GeneticVariation BEFREE Our study revealed two SNPs, rs987539 and rs2074351, within the paraoxonase gene cluster that are associated with susceptibility to sporadic ALS (uncorrected p=6.47E-04 and 7.87E-04, respectively). 18618303

2008