Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1064794259
rs1064794259
LDLR ; MIR6886
0.010 GeneticVariation BEFREE A novel homozygous 1439 C-->T mutation of the LDL-R gene was detected in the patient and his family.ECG showed atypical angina pectoris. 18701038

2008
dbSNP: rs10757278
rs10757278
CDKN2B-AS1
0.010 GeneticVariation BEFREE We found that the rs10757278 GG genotype was significantly associated with recurrent angina compared with the AA and AG genotypes (P = 0.013). 23454037

2013
dbSNP: rs10911021
rs10911021
LINC01344 ; LOC105371642
0.010 GeneticVariation BEFREE Over a median of 9.6 years of follow-up, the risk (C) allele for GLUL rs10911021 was significantly associated with the primary composite end point of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina among individuals with no history of cardiovascular disease (CVD) at baseline using additive genetic models (hazard ratio 1.17 [95% CI 1.01-1.36]; P = 0.032). 26395743

2016
dbSNP: rs1108580
rs1108580
DBH
0.010 GeneticVariation BEFREE The minor alleles of rs1611115 and rs1108580 were associated with sympathetic phenotypes, including angina pectoris. 25326128

2014
dbSNP: rs146243018
rs146243018
GATA6
0.010 GeneticVariation BEFREE 3 potentially pathogenic variants were identified: c.-77G>A in <i>GATA2</i>, p.Ala343Thr (rs370588269) in <i>GATA4</i>, and p.Pro555Ala (rs146243018) in <i>GATA6</i> Multivariate analyses showed that angina was more frequent in patients carrying sarcomeric and GATA rare variants (55% vs 23.2% in non-carriers of GATA rare variants, OR (95% CI) 7.12 (1.23 to 41.27), p=0.029). 28381408

2017
dbSNP: rs1611115
rs1611115
DBH
0.010 GeneticVariation BEFREE The minor alleles of rs1611115 and rs1108580 were associated with sympathetic phenotypes, including angina pectoris. 25326128

2014
dbSNP: rs281432
rs281432
ICAM1
0.010 GeneticVariation BEFREE Multivariate analysis revealed that ICAM-1 SNP rs281432 CC/CG [p=0.016; odds ratio (OR): 2.56, 95% confidence interval (CI): 1.19-5.56], male gender (p=0.018; OR: 1.66, 95% CI: 1.09-2.51), aspirin use in the past 7 days (p=0.001; OR: 2.05, 95% CI: 1.33-3.14), hypertension (p<0.001; OR: 2.15, 95% CI: 1.42-3.25), serum cardiac troponin I elevation (p<0.001; OR: 2.14, 95% CI: 1.47-3.24) and severe angina in recent 24 hours (p=0.001; OR: 1.97, 95% CI: 1.31- 2.95) increase the risk of CAD. 26078712

2015
dbSNP: rs370588269
rs370588269
GATA4
0.010 GeneticVariation BEFREE 3 potentially pathogenic variants were identified: c.-77G>A in <i>GATA2</i>, p.Ala343Thr (rs370588269) in <i>GATA4</i>, and p.Pro555Ala (rs146243018) in <i>GATA6</i> Multivariate analyses showed that angina was more frequent in patients carrying sarcomeric and GATA rare variants (55% vs 23.2% in non-carriers of GATA rare variants, OR (95% CI) 7.12 (1.23 to 41.27), p=0.029). 28381408

2017
dbSNP: rs3742264
rs3742264
CPB2 ; CPB2-AS1
0.010 GeneticVariation BEFREE In France, Thr/Thr carriers of the Ala147Thr polymorphism were significantly more frequent in cases than in controls (p = 0.01) leading to a relative risk of angina pectoris of 2.7 (95%CI 1.2-5.8). 12624641

2003
dbSNP: rs4646156
rs4646156
ACE2
0.010 GeneticVariation BEFREE The AA genotype of rs4646156 had a 7.81× higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). 23077079

2013
dbSNP: rs4977574
rs4977574
CDKN2B-AS1
0.010 GeneticVariation BEFREE In this follow-up study, rs4977574, a tag SNP at chromosome 9p21, was shown to be associated with cardiovascular mortality in Taiwanese patients with angina pectoris but no coronary lesions. 26426617

2015
dbSNP: rs5443
rs5443
GNB3 ; CDCA3
0.010 GeneticVariation BEFREE Effects of lifestyle modification on the progression of coronary atherosclerosis, autonomic function, and angina--the role of GNB3 C825T polymorphism. 16569552

2006
dbSNP: rs7667298
rs7667298
KDR
0.010 GeneticVariation BEFREE In VEGFR-2 -271A>G (rs7667298), the GG carriers had a lower proportion of target lesion revascularization and angina pectoris in contrast to the AA + AG carriers (all P < 0.05). 25738571

2017
dbSNP: rs770696696
rs770696696
LDLR ; MIR6886
0.010 GeneticVariation BEFREE A novel homozygous 1439 C-->T mutation of the LDL-R gene was detected in the patient and his family.ECG showed atypical angina pectoris. 18701038

2008
dbSNP: rs114303883
rs114303883
ABCC6
A 0.700 CausalMutation CLINVAR

dbSNP: rs1481200467
rs1481200467
ABCC6
C 0.700 CausalMutation CLINVAR

dbSNP: rs1555512158
rs1555512158
ABCC6
G 0.700 CausalMutation CLINVAR

dbSNP: rs1555513085
rs1555513085
ABCC6
A 0.700 CausalMutation CLINVAR

dbSNP: rs1555514089
rs1555514089
ABCC6
C 0.700 CausalMutation CLINVAR

dbSNP: rs1555514467
rs1555514467
ABCC6
T 0.700 CausalMutation CLINVAR

dbSNP: rs1555520991
rs1555520991
ABCC6 ; LOC105371100
C 0.700 CausalMutation CLINVAR

dbSNP: rs199473620
rs199473620
SCN5A
A 0.700 CausalMutation CLINVAR

dbSNP: rs2856597
rs2856597
ABCC6
T 0.700 CausalMutation CLINVAR

dbSNP: rs28939702
rs28939702
ABCC6
A 0.700 CausalMutation CLINVAR

dbSNP: rs60791294
rs60791294
ABCC6
T 0.700 CausalMutation CLINVAR