|
rs929626
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling.
|
28630421 |
2017 |
|
rs929626
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 × 10<sup>-7</sup>; OR = 0.7; 95% confidence interval (CI) = 0.61-0.8) with independent replication (P = 0.04), suggesting a variant-mediated dysregulation of leptin signaling may play a role in AN.
|
28630421 |
2017 |
|
rs11174202
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
|
30087453 |
2018 |
|
rs12504244
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
|
30087453 |
2018 |
|
rs75063949
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
|
30087453 |
2018 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism.
|
27271855 |
2016 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No difference was found in minimum BMIs related to Val66Met in AN (one-way ANOVA, P > 0.05).
|
22127997 |
2012 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our analyses indicate that the BDNF Val66Met variant is not associated with AN at detectable levels.
|
21936709 |
2013 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
BDNF has been involved in body weight regulation and its Val66Met polymorphism associated with AN.
|
17197106 |
2007 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Some studies have shown association of BDNF -270C/T single-nucleotide polymorphism (SNP) with bulimia nervosa (BN), while BDNF Val66Met variant has been shown to be associated with both BN and anorexia nervosa (AN).
|
17376155 |
2007 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Case-control studies also suggest a BDNF contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the BDNF gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and -270C/T BDNF SNPs and ED in six different European populations.
|
15657604 |
2005 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients.
|
15115760 |
2004 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Additionally, we genotyped two common polymorphisms (rs6265: p.V66M; c.-46C > T) in 118 patients with anorexia nervosa, 80 patients with bulimia nervosa, 88 patients with ADHD, and 96 normal weight controls.
|
15457498 |
2005 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients.
|
15115760 |
2004 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
BDNF has been involved in body weight regulation and its Val66Met polymorphism associated with AN.
|
17197106 |
2007 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our analyses indicate that the BDNF Val66Met variant is not associated with AN at detectable levels.
|
21936709 |
2013 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism.
|
27271855 |
2016 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Additionally, we genotyped two common polymorphisms (rs6265: p.V66M; c.-46C > T) in 118 patients with anorexia nervosa, 80 patients with bulimia nervosa, 88 patients with ADHD, and 96 normal weight controls.
|
15457498 |
2005 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No difference was found in minimum BMIs related to Val66Met in AN (one-way ANOVA, P > 0.05).
|
22127997 |
2012 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Some studies have shown association of BDNF -270C/T single-nucleotide polymorphism (SNP) with bulimia nervosa (BN), while BDNF Val66Met variant has been shown to be associated with both BN and anorexia nervosa (AN).
|
17376155 |
2007 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Case-control studies also suggest a BDNF contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the BDNF gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and -270C/T BDNF SNPs and ED in six different European populations.
|
15657604 |
2005 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present study explores the effect of a functional polymorphism (Val158Met) in the catechol-O-methyltransferase (COMT) gene on the set-shifting abilities and prefrontal functional connectivity of patients with anorexia nervosa.
|
23046831 |
2013 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate gene for mediating susceptibility to AN since it is involved in the dopamine catabolism and because its functional polymorphism (Val/Met 158) determines high (H) and low (L) enzymatic activity alleles.
|
11317231 |
2001 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I<sup>2</sup> = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I<sup>2</sup> = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I<sup>2</sup> = 0-44%).
|
29057600 |
2017 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association was found between AN-R and several SNPs in the COMT-ARVCF region including the 158Val/Met polymorphism.
|
16118784 |
2005 |