|
rs6269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs6269 was borderline for myofascial pain (OR<sub>c</sub> = 1.82; CI 95%: 0.92-3.59; P = 0.08) and disc displacement (OR<sub>c</sub> = 2.38; CI 95% 0.95-5.97; P = 0.06) and also was associated with anxiety (OR<sub>a</sub> = 2.34; CI 95% 1.04-5.25; P = 0.03).
|
30811655 |
2019 |
|
rs165599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individual COMT SNPs (val158met, rs737865, and rs165599) modulated the association between antenatal maternal anxiety and the prefrontal and parietal cortical thickness in neonates.
|
25320962 |
2015 |
|
rs61910731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism-a prime candidate for anxiety vulnerability-became significantly more anxious during the fMRI experiment (N=97 females: 24 Val/Val, 51 Val/Met, and 22 Met/Met).
|
25238960 |
2014 |
|
rs75012854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs774847933
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety.
|
31156495 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similar findings were observed in the PREDO cohort where maternal prenatal anxiety interacted with child rs4680 to predict symptoms of ADHD at 3.5 years of age.
|
28614354 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analyses suggest that COMT val158met moderates the influence of early life stress on preschool-age symptoms of anxiety.
|
28859863 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our results provide further evidence that 5-HTTLPR and COMT Val(158)Met genotypes influence the vulnerability for the development of anxiety disorders via different mechanisms.
|
25455425 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Applying a multilevel approach, we analyzed the main and interactive effects of the functional COMT val158met polymorphism and L-dopa (single-dose 50 mg levodopa and 12.5 mg carbidopa; double-blind, placebo-controlled design) on the emotion-potentiated (unpleasant, neutral, and pleasant IAPS pictures) startle response as an intermediate phenotype of anxiety in a sample of 100 healthy probands (f = 52, m = 48).
|
25510857 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Based on haplotype trend regression analysis, findings also showed that among rs737865-val158met-rs165599 haplotypes, the A-val-G (AGG) haplotype probabilities modulated positive associations of antenatal maternal anxiety with cortical thickness in the right ventrolateral prefrontal cortex and the right superior parietal cortex and precuneus.
|
25320962 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also found a significant interaction effect of COMT met alleles (β = -32.5 SE 14.1, P = 0.021). in patients genotyped for COMT val158met (N = 87) specifically COMT × conscientiousness (β = 0.73 SE 0.26, P = 0.0042) and COMT × anxiety (β = -0.42 SE 0.16, P = 0.0078) interaction effects.
|
25722948 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated and provided evidence of lower PPI: (i) in healthy pregnant women compared to healthy non-pregnant controls, (ii) in pregnant women with anxiety disorders compared to healthy pregnant women, (iii) in pregnant women with anxiety disorders using SSRI compared to un-medicated pregnant women with anxiety disorders, and (iv) in healthy pregnant women carrying the COMT Val158Met Val/Val genotype compared to Met carriers.
|
26189199 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis provides evidence for sex and ethnic differences in the association of the COMT val158met polymorphism with anxiety traits.
|
24300663 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism-a prime candidate for anxiety vulnerability-became significantly more anxious during the fMRI experiment (N=97 females: 24 Val/Val, 51 Val/Met, and 22 Met/Met).
|
25238960 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interaction of early life experiences with COMT val158met affects anxiety sensitivity.
|
24118915 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val158Met was not associated with anxiety or mood disorders in either gender.
|
23928267 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns = 476 and 409).
|
23475824 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore examined the association of the COMT Val158Met and BDNF Val66Met polymorphisms with BP-II with and without comorbidity of AD, and possible interactions between these genes.
|
23026378 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders.
|
22745815 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli.
|
22387174 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.
|
19944409 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
|
19582565 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed.
|
18578865 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |