Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1063539
rs1063539
0.010 GeneticVariation BEFREE rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients. 31563887

2020

dbSNP: rs11545078
rs11545078
GGH
0.010 GeneticVariation BEFREE The aim of the study was to look for the association of FPGS 2752 G > A (rs1544105), FPGS 1994 A > G (rs10106), and GGH 452 C > T (rs 11545078), GGH -401C > T (rs 3758149) gene polymorphisms with methotrexate (MTX) treatment response and MTX-induced adverse events in South Indian Tamil patients with rheumatoid arthritis (RA). 31611592

2020

dbSNP: rs12342
rs12342
0.010 GeneticVariation BEFREE rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients. 31563887

2020

dbSNP: rs1348254052
rs1348254052
0.010 GeneticVariation BEFREE The aim of the study was to look for the association of FPGS 2752 G > A (rs1544105), FPGS 1994 A > G (rs10106), and GGH 452 C > T (rs 11545078), GGH -401C > T (rs 3758149) gene polymorphisms with methotrexate (MTX) treatment response and MTX-induced adverse events in South Indian Tamil patients with rheumatoid arthritis (RA). 31611592

2020

dbSNP: rs1544105
rs1544105
0.010 GeneticVariation BEFREE The aim of the study was to look for the association of FPGS 2752 G > A (rs1544105), FPGS 1994 A > G (rs10106), and GGH 452 C > T (rs 11545078), GGH -401C > T (rs 3758149) gene polymorphisms with methotrexate (MTX) treatment response and MTX-induced adverse events in South Indian Tamil patients with rheumatoid arthritis (RA). 31611592

2020

dbSNP: rs1800796
rs1800796
0.010 GeneticVariation BEFREE Relationship between polymorphisms in -572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta-analysis. 31782615

2020

dbSNP: rs2069705
rs2069705
0.010 GeneticVariation BEFREE Finally, we verified higher IL-6 value in the RA patients than healthy control group (p = 0.007) and an association between high IL-6 levels and increased CDAI (r = 0.4648, p = 0.0015); DAS 28 (r = 0.3933, p= 0.0091), presence of bone erosions (r = 0.3170, p = 0.0361), ESR levels(r = 0.3041, p = 0.0448) and IFN-γ levels (r = 0.3049, p = 0.0468).Altogether, we suggest that IL10 -1082 (T>C, rs1800896) and INFG -1616(A>G, rs2069705) polymorphisms as well as IL-6 levels alterations may play a role for prognostic and disease follow-up. 31494241

2020

dbSNP: rs2082940
rs2082940
0.010 GeneticVariation BEFREE rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients. 31563887

2020

dbSNP: rs5844572
rs5844572
0.010 GeneticVariation BEFREE The aim of this study was to evaluate the association of MIF promoter polymorphisms (-794CATT<sub>5-8</sub> rs5844572 and -173G > C, rs755622), circulating MIF levels, and mRNA expression with RA susceptibility and disease activity. 31701681

2020

dbSNP: rs7539542
rs7539542
0.010 GeneticVariation BEFREE rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients. 31563887

2020

dbSNP: rs11137037
rs11137037
0.010 GeneticVariation BEFREE The subjects with A/C and C/C genotype of SNP rs11137037 were 1.65 and 2.04 times likely to develop RA than the subjects with A/A genotype. 30745815

2019

dbSNP: rs11203203
rs11203203
0.010 GeneticVariation BEFREE However, we did not detect any significant associations between rs11203203 and RA susceptibility and autoantibody profiles (all p>.05). 30822156

2019

dbSNP: rs117026326
rs117026326
0.010 GeneticVariation BEFREE Genetic variant rs117026326 upstream of the general transcription factor II-I (GTF2I) has been associated with primary Sjögren's syndrome, SLE and RA in East Asian populations. 31520790

2019

dbSNP: rs1234315
rs1234315
0.010 GeneticVariation BEFREE Statistically significant associations with SLE and RA were detected at rs1234315, both by allele analysis (odds ratio 1.47, 95% confidence interval 1.17-1.86, p = 0.001; odds ratio 1.49, 95% confidence interval 1.15-1.92, p = 0.002; respectively), and genotype analysis (p = 0.003 and p = 7.000 × 10<sup>-5</sup>, respectively). 30468820

2019

dbSNP: rs12537
rs12537
0.010 GeneticVariation BEFREE Our results identify a novel role of rs12537 in the susceptibility and progression of RA and SLE, possibly through impacting the interaction between miR-181a and MTMR3 leading to increased autophagy. 31444373

2019

dbSNP: rs12674822
rs12674822
0.010 GeneticVariation BEFREE The subjects with G/T and T/T genotype of SNP rs12674822 were 2.42 and 2.25 times likely to develop RA than the subjects with G/G genotype. 30745815

2019

dbSNP: rs1689334
rs1689334
0.010 GeneticVariation BEFREE This study genotyped blood samples from 214 patients with rheumatoid arthritis (RA) and 293 healthy controls for single nucleotide polymorphisms (SNPs) rs2977537, rs2929970, rs2929973, rs2977530, rs1689334 and rs62514004. 31689765

2019

dbSNP: rs17221959
rs17221959
0.010 GeneticVariation BEFREE CONCLUSIONS This study suggested that the TT genotype and T allele in rs17221959 decreased RA risk. 31316048

2019

dbSNP: rs1805034
rs1805034
0.010 GeneticVariation BEFREE Our meta-analysis found that the rs2277438 polymorphism in <i>RANKL</i> gene inc</span>reased the risk of RA, whereas <i>RANK</i> gene rs1805034</span>, <i>OPG</i> gene rs3102735, <i>OPG</i> gene rs2073618, <i>OPG</i> gene rs3134069 polymorphisms were not related to RA susceptibility. 31209146

2019

dbSNP: rs1823375
rs1823375
0.010 GeneticVariation BEFREE The subjects with G/G genotype of SNP rs1823375 were 1.77 times likely to develop RA than the subjects with C/C genotype. 30745815

2019

dbSNP: rs1870377
rs1870377
KDR
0.010 GeneticVariation BEFREE The rs1870377 KDR variant has shown association with RA under the codominant (<i>p</i> = 0.02, OR = 1.76, 95% CI = 1.09-2.85) and recessive models (<i>p</i> = 0.019, OR = 1.53, 95% CI = 1.07-2.20). 31405022

2019

dbSNP: rs2071559
rs2071559
KDR
0.010 GeneticVariation BEFREE KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54). 31405022

2019

dbSNP: rs2277798
rs2277798
0.010 GeneticVariation BEFREE We also found the genotype distribution and allele frequency of rs2277798 were significantly associated with anti-CCP phenotype in the RA patients (χ<sup>2</sup> = 7.873, p=.020; χ<sup>2</sup> = 4.473, p=.034; respectively). 30822156

2019

dbSNP: rs2281089
rs2281089
0.010 GeneticVariation BEFREE Stratification analysis revealed that two SNPs (rs791588 and rs2281089) were significantly associated with a reduced RA risk in an allele and genetic model after stratification by gender or age (p < 0.05). 31134763

2019

dbSNP: rs2305948
rs2305948
KDR
0.010 GeneticVariation BEFREE KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54). 31405022

2019