|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a concurrent study, the Wellcome Trust Case Control Consortium (WTCCC) has reported strong association of rheumatoid arthritis susceptibility to a different SNP located 3.8 kb from rs10499194 (rs6920220; P = 5 x 10(-6) in WTCCC).
|
17982456 |
2007 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Regarding the rs6920220 SNP, we observed a significant association of the variant allele with SLE (<i>P</i> = 0.03, OR = 1.53), pSS (<i>P</i> = 0.016, OR = 1.69), and RA (<i>P</i> = 0.0001, OR = 2.35) susceptibility.
|
31534975 |
2019 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Median LS was associated with genotype at rs6920220 [LS 31 GG vs 36 GA/AA (p=0.02) in cyclic citrullinated peptide+ (CCP) RA] and rs13020220 [LS 37 GG vs 29 GA/AA (p=0.02) in CCP+ RA] only in autoantibody-positive RA, with no association at rs5029937.
|
22798268 |
2012 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, we were able to replicate the association signals between RA and HLA-DRB1 alleles, STAT4 (rs7574865), PTPN22 (rs2476601) and OLIG3/TNFAIP3 (rs10499194 and rs6920220).
|
19445664 |
2009 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|
18794853 |
2008 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
|
17982456 |
2007 |
|
rs6920220
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Stratification analysis of ethnicity found that rs6920220 and rs5029937 polymorphisms increased the risk of RA among Caucasians, while rs2230926 polymorphism increased the risk of RA among Asians.
|
28199970 |
2017 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results revealed a trend of an association of rs6920220-A allele with RA and genotypes containing this allele were in a higher proportion in RA patients than in matched controls.
|
21833526 |
2012 |
|
rs6920220
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|
18794853 |
2008 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Conversely, 3 of the 27 SNPs (CCR6 rs3093023, TAGAP rs394581, and TNFAIP3 rs6920220) demonstrated ORs in the opposite direction from those reported for RA patients of European ancestry.
|
21120996 |
2010 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data replicate the association of rs6920220 with autoantibody-positive RA disease, although not for rs10499194.
|
19321514 |
2009 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
With the exception of rs6920220, which shows highly consistent results, other proposed markers have high between-study heterogeneity that may reflect unrecognised phenotypic or genetic variability (eg, gene environment interactions) within rheumatoid arthritis.
|
19401279 |
2010 |
|
rs6920220
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
|
rs6920220
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
|
22402800 |
2012 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
|
17982456 |
2007 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared with carriage of none [OR of 1.86 (95% CI) (1.51-2.29)].
|
19417005 |
2009 |
|
rs10499194
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The next most strongly associated SNP was rs13207033 [P = 0.0001, OR (95% CI) 0.86 (0.8-0.93)] which was perfectly correlated with rs10499194, a SNP previously associated with RA in a US/European series.
|
19417005 |
2009 |
|
rs10499194
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA.
|
27779104 |
2016 |
|
rs10499194
|
|
|
0.880 |
GeneticVariation |
BEFREE |
In a concurrent study, the Wellcome Trust Case Control Consortium (WTCCC) has reported strong association of rheumatoid arthritis susceptibility to a different SNP located 3.8 kb from rs10499194 (rs6920220; P = 5 x 10(-6) in WTCCC).
|
17982456 |
2007 |