Gene: STAT4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10168266
rs10168266
STAT4
0.700 GeneticVariation GWASDB Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese. 23028356

2012
dbSNP: rs10168266
rs10168266
STAT4
0.700 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs10174238
rs10174238
STAT4
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655

2019
dbSNP: rs10181656
rs10181656
STAT4
0.820 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs10181656
rs10181656
STAT4
0.820 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs10181656
rs10181656
STAT4
0.820 GeneticVariation BEFREE An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports. 27440135

2017
dbSNP: rs10181656
rs10181656
STAT4
0.820 GeneticVariation BEFREE In addition, rs7574865 and rs10181656, in STAT4, were associated with ACPA-positive RA in the Swedish study. 22753649

2012
dbSNP: rs11889341
rs11889341
STAT4
T 0.800 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs11889341
rs11889341
STAT4
T 0.800 GeneticVariation GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114

2019
dbSNP: rs11889341
rs11889341
STAT4
T 0.800 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs11893432
rs11893432
STAT4
0.700 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs13389408
rs13389408
STAT4
C 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655

2019
dbSNP: rs13426947
rs13426947
STAT4
A 0.800 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs13426947
rs13426947
STAT4
0.800 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs13426947
rs13426947
STAT4
A 0.800 GeneticVariation GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676

2015
dbSNP: rs6749371
rs6749371
STAT4
0.700 GeneticVariation GWASCAT Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis. 26546613

2016
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE Our study indicates that the STAT4 rs7574865 G/T polymorphism was significantly associated with a decreased RA risk in an Asian population. 25179669

2014
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. 27960128

2017
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE To test the hypothesis that the variant haplotype of STAT4 seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant STAT4 haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls. 18273036

2008
dbSNP: rs7574865
rs7574865
STAT4
T 0.900 GeneticVariation GWASDB Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842

2010
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE A higher risk to develop RA was observed for rs7574865 in the STAT-4 gene, while the rs1800872 in the IL-10 gene showed a protective effect. 27342690

2016
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population. 27178308

2016
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE The genotype and allele distributions of four polymorphisms were significantly different in individuals with RA compared to controls, with SNP rs7574865 T allele and T/T genotype showing the most significant association with susceptibility to RA (uncorrected P=1×10(-4), OR=1.645, 95% CI=1.272-2.129; uncorrected P=4.8×10(-5), OR=3.111, 95% CI=1.777-5.447, respectively). 21683716

2011
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation BEFREE In conclusion, this meta-analysis confirms that the STAT4 rs7574865 polymorphism is associated with RA susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. 19588142

2010
dbSNP: rs7574865
rs7574865
STAT4
0.900 GeneticVariation GWASDB Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. 22446963

2012