|
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASDB |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The strong association of the R620W variant of the PTPN22 gene with RA in Caucasians was not replicated since this variant was monomorphic in our study, but other SNP variants of the PTPN22 gene were also not associated with RA in black South Africans, suggesting that this locus does not play a major role in RA in this population.
|
25014791 |
2014 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
These results indicate that PTPN22 C1858T genotype has no effect on response or toxicity outcomes in leflunomide-treated RA patients.
|
25040563 |
2014 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis.
|
23637320 |
2013 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
In conclusion, we found an association between PTPN22 rs2476601 and EGFR rs17337023 polymorphisms and the risk of RA in a sample of Iranian population.
|
23350658 |
2013 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants.
|
23450725 |
2013 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
This meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
|
23370857 |
2013 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
|
21706348 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
RNA was extracted from positively selected CD56+, CD8+, and CD4+ mononuclear cells and the 'residual' cells from 12 RA patients heterozygous for the PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601).
|
22632125 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The +1858C/T single-nucleotide polymorphism (SNP) (rs2476601), in the exon 14 of the PTPN22 gene has been associated with susceptibility to RA in several population.
|
22743847 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.
|
22704547 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASDB |
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
|
22446963 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis.
|
22427951 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D).
|
21467606 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We found that PTPN22 1858C/T polymorphism could increase RA risk in overall genetic models in Europeans (T-allele vs. C-allele, OR = 1.54, 95% CI = 1.47-1.62, P(heterogeneity) = 0.143; TT vs. CC, OR = 2.86, 95% CI = 2.29-3.57, P(heterogeneity) = 0.302; TC vs. CC, OR = 1.45, 95% CI = 1.38-1.53, P(heterogeneity) = 0.273; TT + TC vs. CC, OR = 1.49, 95% CI = 1.42-1.56, P(heterogeneity) = 0.208; TT vs. TC + CC, OR = 2.52, 95% CI = 1.95-3.25, P(heterogeneity) = 0.296).
|
22209972 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
This association is independent of the well-established association between PTPN22 R620W and RA.
|
21279993 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis.
|
21949702 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASCAT |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our study suggests that the PTPN22 C1858T polymorphism acts as a susceptibility gene for autoantibody-positive RA in Turkey.
|
21506938 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The SNP rs2476601 located in the PTPN22 gene is the sole common genetic variant associated with RA in the 1p13.2 region, suggesting that neighbor genes of PTPN22 do not have a major influence in RA.
|
21965649 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The aim of this study was to assess whether the C1858T polymorphism of PTPN22 also confers increased risk for SLE and RA in the genetically homogeneous population of Crete.
|
21543514 |
2011 |