|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our data suggest that the PTPN22 C1858T single nucleotide polymorphism has no or minor effect on RA and AITDs susceptibility in the Tunisian population.
|
19343596 |
2009 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of PTPN22 gene.
|
19357851 |
2009 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We have no evidence for a common variant additional to rs2476601 within the PTPN22 locus that influences the risk of RA.
|
20975833 |
2010 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.
|
20498205 |
2010 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.
|
20888443 |
2010 |
|
rs1310182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We compared the allele frequencies of five haplotype-tagging SNPs in the PTPN22 gene, 2 of which are reportedly associated with RA in Caucasians (rs3789604 and rs1310182), and compared haplotype distributions between 184 Japanese T1D patients and 179 healthy controls. rs3789604 was not associated with T1D in our Japanese subjects.
|
20510318 |
2010 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
This association is independent of the well-established association between PTPN22 R620W and RA.
|
21279993 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
To investigate genotype-phenotype correlation and gene-environment interaction between PTPN22 R620W environmental factors such as tobacco/hormonal treatments in an inception cohort of RA patients.
|
21752868 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The SNP rs2476601 located in the PTPN22 gene is the sole common genetic variant associated with RA in the 1p13.2 region, suggesting that neighbor genes of PTPN22 do not have a major influence in RA.
|
21965649 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis.
|
21949702 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We found that PTPN22 1858C/T polymorphism could increase RA risk in overall genetic models in Europeans (T-allele vs. C-allele, OR = 1.54, 95% CI = 1.47-1.62, P(heterogeneity) = 0.143; TT vs. CC, OR = 2.86, 95% CI = 2.29-3.57, P(heterogeneity) = 0.302; TC vs. CC, OR = 1.45, 95% CI = 1.38-1.53, P(heterogeneity) = 0.273; TT + TC vs. CC, OR = 1.49, 95% CI = 1.42-1.56, P(heterogeneity) = 0.208; TT vs. TC + CC, OR = 2.52, 95% CI = 1.95-3.25, P(heterogeneity) = 0.296).
|
22209972 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D).
|
21467606 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The aim of this study was to assess whether the C1858T polymorphism of PTPN22 also confers increased risk for SLE and RA in the genetically homogeneous population of Crete.
|
21543514 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our study suggests that the PTPN22 C1858T polymorphism acts as a susceptibility gene for autoantibody-positive RA in Turkey.
|
21506938 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We genotyped SNPs rs3761847 and rs7021206 at the TRAF1/C5 locus and rs2476601 SNP in the PTPN22 gene in a Han Chinese cohort composed of 576 patients with RA and 689 controls.
|
21492465 |
2011 |
|
rs33996649
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings indicate that the minor allele of the PTPN22 R263Q polymorphism is associated with a lower risk of RA.
|
21279993 |
2011 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
|
21706348 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The +1858C/T single-nucleotide polymorphism (SNP) (rs2476601), in the exon 14 of the PTPN22 gene has been associated with susceptibility to RA in several population.
|
22743847 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
RNA was extracted from positively selected CD56+, CD8+, and CD4+ mononuclear cells and the 'residual' cells from 12 RA patients heterozygous for the PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601).
|
22632125 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.
|
22704547 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis.
|
22427951 |
2012 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
This meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
|
23370857 |
2013 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants.
|
23450725 |
2013 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis.
|
23637320 |
2013 |