rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> Our results showed that the MTHFR [677C>T (rs1801133)] TT genotype is associated with ADRs to MTX in Chinese RA patients.
|
30546311 |
2018 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism was associated with HHC in RA patients (multi-adjusted OR, 95% CI 2.18, [1.07-4.57]; p = 0.031).
|
29796841 |
2018 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis results demonstrate that the MTHFR C677T polymorphism is involved in the genetic susceptibility of RA in Asians, and the MTHFR A1298C polymorphism is associated with genetic susceptibility to RA in the overall population.
|
27423206 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The absence of TYMS 1494 del6 and FPGS rs10106 and presence of MTHFR C677T predict adverse events in RA patients treated with MTX.
|
27992285 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C677T MTHFR gene polymorphism is associated with RA in Egyptians.
|
28215593 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis.
|
26599798 |
2016 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results demonstrated that the C677T polymorphism in the MTHFR gene is associated with MTX toxicity in Tunisian RA patients.
|
26077125 |
2016 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several authors have reported contradictory results related to C677T polymorphism in the MTHFR gene and response to MTX in RA.
|
26314492 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T was associated with RA using all models except the recessive model.
|
26147289 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that the MTHFR C677T and A1298C polymorphisms are associated with MTX toxicity in RA patients.
|
24794492 |
2014 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to elucidate the role of methylenetetrahydrofolate reductase (MTHFR) C677T and aminoimidazole carboxamide adenosine ribonucleotide transformylase (ATIC) T675C polymorphisms and clinicopathological variables in clinical response to MTX in Portuguese RA patients.
|
24967362 |
2014 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that there is an association of IL-4 gene 70bp VNTR polymorphism and MTHFR C677T polymorphism with susceptibility of a person for development of RA.
|
23685257 |
2013 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The available evidence suggests that the MTHFR C677T and A1298C gene polymorphisms are not reliable predictors of response to MTX treatment in RA patients.
|
21931346 |
2013 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexate-related toxicities in Korean patients with rheumatoid arthritis.
|
21773884 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that the presence of the MTHFR C677T and ABCB1 C3435T SNPs contribute to MTX toxicity in patients with RA.
|
23095111 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The associations of the MTHFR C677T polymorphism with osteoporosis/osteopenia and femoral neck BMD suggest that these polymorphisms confer a risk of developing osteoporosis in patients with rheumatoid arthritis, a risk that may be reduced with folate and B complex supplementation.
|
22377704 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results demonstrate that the C677T polymorphism in the MTHFR gene is associated with MTX toxicity in a Spanish RA population.
|
22044028 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis including 1514 patients with RA found no association between the C677T and A1298C polymorphisms of MTHFR and the toxicity and efficacy of methotrexate in RA.
|
20067328 |
2010 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We determined the contribution of the methylene tetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C gene polymorphisms to the susceptibility to rheumatoid arthritis (RA).
|
20423475 |
2010 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we conclude that homocysteine might affect the inflammatory status of patients, and the MTHFR 677C>T SNP could be a predictive factor of hyperhomocysteinemia in patients with RA.
|
19283524 |
2009 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It has been suggested that common polymorphisms in its gene (C677T and A1298C) could be related to different methotrexate (MTX) response and toxicity in rheumatoid arthritis (RA) patients.
|
19604445 |
2009 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although RA remission rate in carriers of the MTHFR 677T and 1298C alleles was more frequently observed, it does not seem that 677C>T and 1298A>C MTHFR polymorphisms have a major influence on treatment outcome in RA patients treated with sulfasalazine.
|
19578646 |
2009 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine the association between 677C > T and 1298A > C MTHFR polymorphisms and arechin efficacy in the treatment of RA, a total of 50 RA patients, treated with arechin were analyzed.
|
18195462 |
2008 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine the association between 677C>T and 1298A>C MTHFR polymorphisms and MTX efficacy in the treatment of RA, a total of 174 RA patients, treated with MTX plus methylprednisone 4 mg and folic acid 5 mg were analyzed.
|
18034620 |
2007 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism may be an important predictor of MTX-related toxicity in patients with RA.
|
16758511 |
2006 |