Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.070 | GeneticVariation | BEFREE | IL-17A rs2275913 and IL-17F rs763780 polymorphisms are significantly associated with susceptibility to RA and with different clinical characteristics of this disease. | 31454755 | 2020 |
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0.070 | GeneticVariation | BEFREE | The aim of this study was to investigate whether the IL-17A -737 T/C (rs8193036), -444A/G (rs3819024), -197G/A (rs2275913), and -121G/A (rs8193037) SNPs conferred susceptibility to SLE (or lupus nephritis) or to RA in a Mexican population. | 30398030 | 2019 |
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0.070 | GeneticVariation | BEFREE | Knowing this, the aim of this study was to investigate the association of +2199 A/C IL-23R (rs10889677), -197 G/A IL-17A (rs2275913), and +7488 A/G IL-17F (rs763780) gene polymorphisms with RA susceptibility and clinical features in a Brazilian population. | 28547498 | 2017 |
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0.070 | GeneticVariation | BEFREE | We found evidence of associations between RA and alleles from the <i>IL-17A</i> rs2275913 and <i>IL-17F</i> rs763780 polymorphisms in Caucasians (p=0.003 and p=0.037, respectively). | 28069745 | 2017 |
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0.070 | GeneticVariation | BEFREE | In summary, our pooled analysis indicated that the IL-17A (rs2275913) and IL17F (rs763780 T/C) increased the RA risk. | 28186427 | 2017 |
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0.070 | GeneticVariation | BEFREE | Our results indicated that IL17A rs4711998 A/G and IL17A rs8193037 G/A polymorphisms were not associated with RA, and IL17A rs2275913 G/A and IL17A rs3819024 A/G variant alleles decrease the risk of RA, while IL17A rs3819025 G/A and IL17A rs8193036 C/T variant alleles increase the risk of RA. | 25871515 | 2015 |
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0.070 | GeneticVariation | BEFREE | The present study aimed to determine the association between the polymorphic variants of the IL-17A (rs2275913), IL-17F (rs763780) and IL-23R (rs11209026) genes and RA susceptibility, progression and response to therapy with TNF-α inhibitors. | 25387578 | 2015 |