Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.770 | GeneticVariation | BEFREE | Overall, the IL-21 rs6822844 G/T polymorphism was found to be significantly associated with decreased RA risk (eg: T-allel</span>e vs. G-allele: OR= 0.81, 95% CI= 0.72-0.91, P < 0.001). | 31763680 | 2020 |
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0.770 | GeneticVariation | BEFREE | For IL-21, rs6822844 and rs4505848 were described to have significant associations with susceptibility to RA. | 31454755 | 2020 |
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0.770 | GeneticVariation | BEFREE | Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility. | 31366568 | 2019 |
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0.770 | GeneticVariation | BEFREE | This study indicates for the first time that there is a strong association between IL2/IL21 rs6822844 variant and susceptibility to RA in the Algerian population, and that this association was independent from the autoantibodies status of RA patients. | 26917059 | 2016 |
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0.770 | GeneticVariation | GWASDB | High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. | 23143596 | 2012 |
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0.770 | GeneticVariation | BEFREE | When combined in a meta-analysis using data from a total of 9,772 cases and 10,909 controls there was a genome-wide level of significance supporting association of rs6822844 with RA (OR=0.86 (0.82 to 0.91), P=8.8x10(-8), P=2.1x10(-8) including North American Rheumatoid Arthritis Consortium data). | 20553587 | 2010 |
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0.770 | GeneticVariation | BEFREE | We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM (P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). | 20112382 | 2010 |
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0.770 | GeneticVariation | BEFREE | We tested SNP rs6822844 for association with disease in 350 T1D-affected and 1,047 rheumatoid arthritis (RA)-affected Dutch patients and in 929 controls. | 17999365 | 2007 |