|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the RFC-1 80G>A (rs1051266) SNP exerts a potentially protective effect against the risk of adverse drug reactions in Chinese RA patients treated with MTX.
|
31099054 |
2019 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In multivariate analysis, patients with the solute carrier family 19 member 1 (SLC19A1) 80G>A A/A genotype had a better response than those with the A/G or G/G genotype, and patients with the C allele of γ-glutamyl hydrolase (GGH) 16T>C had a better response than those with the T/T genotype.This study showed that the therapeutic response to MTX in Japanese RA patients was associated with the genetic polymorphisms of SLC19A1 80G>A and GGH 16T>C in actual clinical practice.
|
30175777 |
2018 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
RFC-1 80G > A gene polymorphism confers protection for RA.
|
25771854 |
2016 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the RFC1 G80A polymorphism is associated with responsiveness to MTX therapy, but may not be associated with MTX toxicity in RA patients.
|
27233001 |
2016 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study was to characterize the association of clinicopathological variables and the SLC19A1/RFC-1 G80A polymorphism in methotrexate (MTX)-related toxicity in Portuguese patients with rheumatoid arthritis.
|
24350725 |
2014 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In these analyses of available data from observational studies, RFC1 80G>A was found to be associated with MTX efficacy, but not toxicity, in RA patients.
|
24782176 |
2014 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study suggest that the RFC1 G80A polymorphism may be a useful marker for predicting MTX efficacy in Japanese patients with RA.
|
22971639 |
2013 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Frequencies of MTHFR C677T and A1298C were similar to those reported in Japanese RA patients, while frequencies of RFC-1 G80A genotypes differed from those reported in RA patients in the United States.
|
17965559 |
2007 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present data suggest that evaluation of RFC-1 gene 80G>A polymorphism may be a useful tool to optimize MTX therapy in patients with RA.
|
17325736 |
2007 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the contribution of common genetic polymorphisms in RFC-1 (G80A), ATIC (C347G), and TS (28-bp tandem repeats located in the TS enhancer region [TSER*2/*3]) and of MTXPGs to the effect of MTX in patients with rheumatoid arthritis.
|
15457444 |
2004 |
|
rs775144154
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether polymorphisms in reduced folate carrier (SLC19A1 G80A) and gamma-glutamyl-hydrolase (GGH-401C/T) are predictive of methotrexate polyglutamate (MTXPG) levels in patients with rheumatoid arthritis treated with weekly low-dose methotrexate (MTX).
|
15564880 |
2004 |