Gene: PADI4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2240335
rs2240335
PADI4
0.810 GeneticVariation BEFREE Here, we determine if single nucleotide polymorphism rs2240335 in <i>PADI4</i>, whose G allele is associated with reduced PAD4 in neutrophils, correlates with NETs, anti-histone antibodies, and rheumatoid arthritis susceptibility in North Americans. 31242568

2019
dbSNP: rs2240335
rs2240335
PADI4
0.810 GeneticVariation GWASCAT The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. 21505073

2011
dbSNP: rs2240335
rs2240335
PADI4
0.810 GeneticVariation GWASCAT Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. 21452313

2011
dbSNP: rs2240335
rs2240335
PADI4
0.810 GeneticVariation GWASDB Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. 21452313

2011
dbSNP: rs2240335
rs2240335
PADI4
0.810 GeneticVariation GWASDB The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. 21505073

2011
dbSNP: rs2301888
rs2301888
PADI4
A 0.800 GeneticVariation GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114

2019
dbSNP: rs2301888
rs2301888
PADI4
A 0.800 GeneticVariation GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676

2015
dbSNP: rs2301888
rs2301888
PADI4
G 0.800 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs2301888
rs2301888
PADI4
G 0.800 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs2240336
rs2240336
PADI4
0.800 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs2240336
rs2240336
PADI4
0.800 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs2240339
rs2240339
PADI4
0.800 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs2240339
rs2240339
PADI4
A 0.800 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE This work supports the association of the T allele of PADI4 rs2240340 with RA in Asians. 28653215

2017
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE Failure to replicate the association of PADI4(rs2240340)/(PADI4_94) in Egyptian RA patients provides further support for the notion that genetic architecture of RA is different in multiple populations of European, Asian, African, and Middle Eastern ancestries. 27125674

2016
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE RA risk genotypes of PADI4 were specifically associated with anti-CCP positive RA (rs2240340: p=5.13×10⁻⁶; rs1748033: p=2.97×10⁻³, respectively). 24564960

2014
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE These findings suggest that the functional single-nucleotide polymorphism PADI4 rs2240340 G/A variant allele is associated with RA development, especially among older patients and ACPA-positive patients. 22505706

2012
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE The PADI4_94 (rs2240340) single nucleotide polymorphism (SNP) was directly genotyped in a cohort of unrelated UK Caucasian patients with RA (n=3732) and population controls (n=3039). 19470526

2010
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII. 18462498

2008
dbSNP: rs2240340
rs2240340
PADI4
0.770 GeneticVariation BEFREE Only the SNP rs2240340/padi4_94 was modestly associated with RA [allele odds ratio (OR) 1.22, 95% confidence interval (CI) 1.04-1.43, P=0.012]. 18087673

2008
dbSNP: rs2240340
rs2240340
PADI4
C 0.770 GeneticVariation CLINVAR

dbSNP: rs11203366
rs11203366
PADI4
0.720 GeneticVariation BEFREE We addressed the relationship between three exonic PADI4 gene single nucleotide polymorphisms (SNPs) PADI4_89 (rs11203366), PADI4_90 (rs11203367) and PADI4_92 (rs874881) and related haplotypes with RA in a population from Southern México. 28551357

2017
dbSNP: rs11203366
rs11203366
PADI4
0.720 GeneticVariation GWASDB Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. 21452313

2011
dbSNP: rs11203366
rs11203366
PADI4
0.720 GeneticVariation BEFREE Herein, we further investigate whether RA risk PADI4 haplotype (SNP PADI4; S55G, A82V and A112G) and the increase of its enzymatic activity induce apoptosis. 17216583

2007
dbSNP: rs11203368
rs11203368
PADI4
0.700 GeneticVariation GWASDB Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. 21452313

2011