rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Our data do not support an influence of MHCIITA rs3087456 and rs4774 polymorphisms in the increased risk of CV events of patients with RA.
|
22272574 |
2012 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Meta-analysis of 16 RA cohorts confirmed rs3087456 with only marginal significance (P=0.016).
|
22513452 |
2012 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Similar analysis of three independent RA cohorts from British, Dutch and Norwegian populations also indicated an absence of significant interaction between genetic variants in CIITA and SE alleles with regard to RA risk.Our data suggest that risk from the CIITA locus is independent of the major risk for RA from HLA-DRB1 SE alleles, given that no significant interaction between rs3087456 and SE alleles was observed.
|
22461888 |
2012 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
A promoter SNP -168A→G (rs3087456) has previously been shown to be associated with susceptibility to several immune mediated disorders, including rheumatoid arthritis (RA), multiple sclerosis (MS) and myocardial infarction (MI).
|
20942939 |
2010 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Our results indicate that the MHC2TA -168A/G polymorphism (rs3087456) is not associated with RA yet underscore the importance of including shared epitope allele carrier status, secondary phenotypes and more complete characterisation of MHC2TA variation in future studies.
|
17875550 |
2008 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction in a northern European population.
|
17012290 |
2007 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients.
|
16920747 |
2007 |
rs3087456
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We analysed whether the single nucleotide polymorphism (SNP) rs3087456 in the promoter of the MHC class II transactivator (MHC2TA) gene is associated with manifestation of rheumatoid arthritis, multiple sclerosis, narcolepsy and Wegener granulomatosis.
|
16426246 |
2006 |
rs3087456
|
|
G |
0.780 |
SusceptibilityMutation |
CLINVAR |
|
|
|
rs4774
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (-168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (-169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes.
|
26350270 |
2016 |
rs4774
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data do not support an influence of MHCIITA rs3087456 and rs4774 polymorphisms in the increased risk of CV events of patients with RA.
|
22272574 |
2012 |
rs8048002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs3087456 and rs8048002 were significantly associated with RA (combined Norwegian and Swedish patients P(corrected)=0.012 and P(corrected)=0.0016, respectively), but not with JIA or T1D.
|
22513452 |
2012 |