Source: ALL
Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042714
rs1042714
0.100 GeneticVariation BEFREE We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma. 7739309

1995

dbSNP: rs1042713
rs1042713
0.100 GeneticVariation BEFREE In the asthma group, one mutation (Arg16-->Gly) identified a subset of patients with a distinct clinical profile.(ABSTRACT TRUNCATED AT 250 WORDS) 8383511

1993

dbSNP: rs199929962
rs199929962
0.010 GeneticVariation BEFREE Sequence analysis of the IL9 gene in three patients sharing a possibly conserved haplotype revealed a T113M coding polymorphism, but this variant showed no association with either serum IgE levels or asthma. 9328470

1997

dbSNP: rs1042713
rs1042713
0.100 GeneticVariation BEFREE Polymorphisms at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamic acid) of the beta2-adrenoreceptor (B2AR) gene are known to be functionally relevant and have been associated with more severe forms of asthma, nocturnal asthma and decreased airway responsiveness in asthmatic subjects. 10469027

1999

dbSNP: rs1042714
rs1042714
0.100 GeneticVariation BEFREE Polymorphisms at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamic acid) of the beta2-adrenoreceptor (B2AR) gene are known to be functionally relevant and have been associated with more severe forms of asthma, nocturnal asthma and decreased airway responsiveness in asthmatic subjects. 10469027

1999

dbSNP: rs79908535
rs79908535
0.020 GeneticVariation BEFREE A novel variant of human IL-13, Gln110Arg, on chromosome 5q31, associated with asthma rather than IgE levels in case-control populations from Britain and Japan [peak odds ratio (OR) = 2.31, 95% CI 1.33-4.00]; the variant also predicted asthma and higher serum IL-13 levels in a general, Japanese paediatric population. 10699178

2000

dbSNP: rs4523
rs4523
0.030 GeneticVariation BEFREE Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene. 10830912

2000

dbSNP: rs1042713
rs1042713
0.100 GeneticVariation BEFREE Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10). 10934093

2000

dbSNP: rs1042714
rs1042714
0.100 GeneticVariation BEFREE Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10). 10934093

2000

dbSNP: rs10800812
rs10800812
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs1229598
rs1229598
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs17064520
rs17064520
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs2153101
rs2153101
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs2538026
rs2538026
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs4436440
rs4436440
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs4950929
rs4950929
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs545854
rs545854
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs946263
rs946263
0.700 GeneticVariation GWASDB A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. 11022011

2000

dbSNP: rs4987053
rs4987053
0.020 GeneticVariation BEFREE In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found. 11307756

2001

dbSNP: rs34586275
rs34586275
0.010 GeneticVariation BEFREE Within the muscarinic M(2) receptor gene, we identified two degenerate single base substitutions (1197T-->C, Thr-->Thr and 976A-->C, Arg-->Arg) in one random and one asthmatic sample respectively. 11325793

2001

dbSNP: rs1800072
rs1800072
0.010 GeneticVariation BEFREE Three potentially disease-causing mutations, T388 M, M1R and V11I, are novel, found so far only in three asthma patients. 11354633

2001

dbSNP: rs1042713
rs1042713
0.100 GeneticVariation BEFREE Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma. 11371409

2001

dbSNP: rs1042714
rs1042714
0.100 GeneticVariation BEFREE Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma. 11371409

2001

dbSNP: rs1805014
rs1805014
0.010 GeneticVariation BEFREE The central objective of this study was to elucidate the role of the Ser786Pro polymorphism in asthma and its impact on IL-4R function. 11513543

2001

dbSNP: rs112228717
rs112228717
0.020 GeneticVariation BEFREE By considering the probands and their spouses as an unrelated sample, we observed significant associations of atopy and asthma-related phenotypes with several IL4RA polymorphisms, including S478P and total serum IgE levels (P=.0007). 11709756

2002