rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma.
|
26125920 |
2015 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There were no significant associations between SNP rs7216389 and asthma.
|
24735179 |
2014 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Asthma diagnosis was associated with rs11650680 and five other SNPs including rs7216389 (P = 0.019-0.034), whereas atopy was associated only with rs11650680 (P = 0.0004).
|
19175592 |
2009 |
rs7216389
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
|
17611496 |
2007 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs7216389 was significantly associated with the development of wheeze (hazard ratio 1.64 [1.05-2.59], P value = 0.03), asthma (hazard ratio, 1.88 [1.15-3.07], P = 0.01), and acute severe exacerbations (hazard ratio 2.66 [1.58-4.48], P value = 0.0002).
|
19029000 |
2009 |
rs7216389
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
|
17611496 |
2007 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Stronger effect sizes were observed between GWAS SNPs and gene expression in placentas than what has been reported in other tissues, such as the correlation between asthma risk allele, rs7216389-T and Gasdermin-B (GSDMB) in placenta (r2=27%) versus lung (r2=6%).
|
28854703 |
2017 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The diagnosis of asthma was associated with rs7216389 in ORMDL3 [odds ratio (OR) 0.74 and 95% confidence interval (95% CI) 0.56-0.99] and rs3756780 in ARG1 (OR 0.67, 95% CI 0.51-0.89) and BDR with rs2749935 in ARG1.
|
22472724 |
2012 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of this meta-analysis firmly established that genetic variation at the rs7216389 locus, which controls the expression of the ORMDL3, may be a major, independent predisposing factor for asthma in ethnically diverse populations.
|
25167772 |
2014 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis of five published studies on rs7216389 in nine populations gave an odds ratio for asthma of 1.44 (95% CI, 1.35-1.54, P < 0.00001).
|
19133921 |
2009 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking.
|
25331618 |
2015 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
|
24406073 |
2014 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The haplotype (CAA) of rs7216389, rs4794820 and rs4065275 was associated with a lower risk of asthma susceptibility and a higher logPC(20).
|
22732088 |
2012 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between methylation and asthma was independent of the genotype in rs7216389, rs4065275 and rs12603332.
|
25256354 |
2015 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Thus, the contribution of rs7216389-T to the development of asthma is unlikely to operate only through an impact on the expression of ORMDL3 or GSDMB genes.
|
20372189 |
2010 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Cat and/or dog exposure from birth was associated with a lower prevalence of asthma among children with the rs7216389 high-risk TT genotype (adjusted hazard ratio, 0.16; 95% CI, 0.04-0.71; P = .015), with no effect in those with the CC/CT genotype (adjusted P = .283), demonstrating interaction between cat and dog exposure and the rs7216389 genotype (adjusted P = .044).
|
29102067 |
2018 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389).
|
21337730 |
2011 |