|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96).
|
26534891 |
2016 |
|
rs2305480
|
|
G |
0.860 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Two coding variants (rs2305480 and rs11078928) of the gasdermin B (GSDMB) gene in the 17q21 locus were associated with lower asthma risk in both GERA (odds ratio, 0.92; P = 1.01 × 10<sup>-6</sup>) and EVE (odds ratio, 0.85; joint P<sub>EVE</sub> = 1.31 × 10<sup>-13</sup>).
|
29330013 |
2018 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
For two of these six loci (rs2305480 and rs8067378), there was evidence of association with asthma, and there was a weak association of asthma with rs8069176.
|
22370936 |
2012 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma.
|
23841068 |
2013 |
|
rs1295686
|
|
T |
0.840 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs1295686
|
|
T |
0.840 |
GeneticVariation |
GWASCAT |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96).
|
26534891 |
2016 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population.
|
29211635 |
2018 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
|
26365633 |
2016 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
C/C genotype of rs1342326 [OR (95% CI) 2.50 (1.33-4.69)] and A/A genotype of rs3939286 [OR (95% CI) 2.18 (1.05-4.52)] were associated with higher risk of asthma development.
|
31820077 |
2020 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The presence of rs1342326 polymorphism was significantly associated with a lower risk of asthma development.
|
28985997 |
2018 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05).
|
30950351 |
2019 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
rs1342326
|
|
C |
0.840 |
GeneticVariation |
GWASDB |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
rs1342326
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
rs1837253
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively).
|
20560908 |
2010 |
|
rs1837253
|
|
|
0.840 |
GeneticVariation |
GWASCAT |
Identification of Four Novel Loci in Asthma in European American and African American Populations.
|
27611488 |
2017 |
|
rs1837253
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |