|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
C/C genotype of rs1342326 [OR (95% CI) 2.50 (1.33-4.69)] and A/A genotype of rs3939286 [OR (95% CI) 2.18 (1.05-4.52)] were associated with higher risk of asthma development.
|
31820077 |
2020 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The presence of rs1342326 polymorphism was significantly associated with a lower risk of asthma development.
|
28985997 |
2018 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05).
|
30950351 |
2019 |
|
rs1342326
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
rs1837253
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively).
|
20560908 |
2010 |
|
rs1837253
|
|
|
0.840 |
GeneticVariation |
BEFREE |
rs1837253 is associated with asthma susceptibility and may increase the risk of asthma in Zhuang people in Guangxi.
|
31066119 |
2019 |
|
rs1837253
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Surprisingly, rs1837253 (consistently associated with asthma) showed no correlation with TSLP expression levels.
|
26119467 |
2015 |
|
rs1837253
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Recent candidate gene and genome-wide association studies have identified "protective" associations between the single-nucleotide polymorphism (SNP) rs1837253 in the TSLP gene and risk for allergy, asthma, and airway hyperresponsiveness.
|
25515628 |
2015 |
|
rs11071559
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Our results provided evidence that the RORA rs11071559C>T polymorphism was associated with an elevated susceptibility to pediatric asthma in the Chinese Zhuang population.
|
29282706 |
2018 |
|
rs11071559
|
|
|
0.820 |
GeneticVariation |
BEFREE |
To investigate the impact of RORA on asthma susceptibility, we performed a genetic association study between RORA single nucleotide polymorphisms (SNPs) in the vicinity of the asthma-associated SNP (rs11071559) and asthma-related traits.
|
23565190 |
2013 |
|
rs11071559
|
|
|
0.820 |
GeneticVariation |
BEFREE |
By haplotype analyses, the haplotype TT (rs7164773/rs11071559) was statistically significant between asthmatics and nonasthmatics, but the association was not significant after correction for multiple comparisons.
|
29282706 |
2018 |
|
rs11078927
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We applied ASElux to 273 lung RNA-seq samples from GTEx and identified a splice-QTL rs11078928 in lung which explains the mechanism underlying an asthma GWAS SNP rs11078927.
|
29186329 |
2018 |
|
rs11078927
|
|
|
0.820 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
|
rs2244012
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Multiple SNPs in the RAD50-IL13 region on chromosome 5q31.1 were associated with asthma: rs2244012 in intron 2 of RAD50 (P = 3.04E-07).
|
20159242 |
2010 |
|
rs2244012
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
|
26365633 |
2016 |
|
rs2290400
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Sixteen SNPs were significantly associated with asthma after multiple testing correction (P ≤ .01), of which 5 (rs2290400, rs8079416, rs3894194, rs7212938, and rs3859192) were strongly associated (FDR P ≤ .0002), and one was novel (IKZF3-rs1453559).
|
22626592 |
2012 |
|
rs2290400
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Haplotypes at 17q12-q21 encompassing rs2290400 are known to determine the susceptibility of early-onset asthma by affecting the expression of flanking genes.
|
27352912 |
2016 |
|
rs3771180
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
|
rs3771180
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Association of IL1RL1 rs3771180 and TSLP rs1837253 variants with asthma in the Guangxi Zhuang population in China.
|
31066119 |
2019 |
|
rs3859192
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The present study reports that the polymorphic genomic variant rs3816470 is significantly and independently associated with asthma in the studied population, while the variants, rs6503525 and rs3859192, also indicate a significant association with asthma in this population when family history of the disease is taken as a covariate.
|
26203825 |
2015 |
|
rs3859192
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We observed significant interaction between 5 SNPs and smoking on AHR, and 3 interacted with smoking in relation to asthma with AHR (rs4795404, rs4795408, rs3859192</span>).
|
22626592 |
2012 |
|
rs4129267
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with respect to asthma severity.
|
22554704 |
2012 |
|
rs4129267
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
|
21907864 |
2011 |
|
rs7212938
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389).
|
21337730 |
2011 |
|
rs7212938
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In LD block1 (93 kb) consisting of six SNPs (rs12936231, rs7216389, rs7216558, rs9894164, rs1007654 and rs7212938), none of the haplotypes show any significant association with asthma except the haplotype "CCTCAG", which is a significant protective factor against asthma having frequency 0.051 in controls while 0.017 in cases (p = 3.56 × 10(-2), χ2 = 4.415).
|
26203825 |
2015 |