rs61735175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs61735175 was positively associated with asthma severity in the additive model (OR 1.72, 95% CI 1.07-2.77) and in the dominant model (OR 1.77, 95% CI 1.09-2.85).
|
31126515 |
2019 |
rs6692977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the frequencies of the rs6692977 CT genotype and T allele within FCRL5 were significantly higher in asthma with comorbid AR compared to healthy controls (Bonferroni-corrected p (Pc) = 3.75 × 10<sup>-6</sup>; Pc = 0.006, respectively), whereas these of the CC genotype and C allele were significantly lower (Pc = 4.15 × 10<sup>-5</sup>; Pc = 0.006, respectively).
|
30771554 |
2019 |
rs7528684
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the rs7528684 A allele (Pc = 1.80 × 10<sup>-3</sup>) and the rs10489678 G allele (Pc = 0.04) within FCRL3 were higher in asthma with comorbid AR than in controls.
|
30771554 |
2019 |
rs755348141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Clinical studies report that the population variant Gln27Glu is associated with a differential response to common asthma drugs, such as albuterol, isoproterenol and terbutaline.
|
31520159 |
2019 |
rs7635009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of <i>MYH15</i> and may be functional variants conferring susceptibility to asthma.
|
30906771 |
2019 |
rs766736182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study reveals that SNP rs766736182 of interleukin-7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma.
|
30239047 |
2019 |
rs833069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ADAM33 rs528557/S2 and the VEGFA rs833069 SNPs were associated with Thai asthmatics, as well as with other populations worldwide.
|
31586488 |
2019 |
rs9288876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of <i>MYH15</i> and may be functional variants conferring susceptibility to asthma.
|
30906771 |
2019 |
rs946261
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the Tsukuba GWAS cohort, the C allele at rs946261 was significantly associated with reduced expression of CHI3L1 mRNA in the lung and with development of asthma (odds ratio (OR) 1.27; P = 0.036).
|
30940096 |
2019 |
rs10877012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12794714 and rs10877012 SNPs were associated with asthma risk.
|
29502202 |
2018 |
rs1135216
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis by atopic types indicated significant association of TAP1 polymorphism rs1135216 with asthma in the allele, dominant and recessive models and with allergic rhinitis in the recessive model.
|
29416713 |
2018 |
rs11651270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children.
|
29154202 |
2018 |
rs12150220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children.
|
29154202 |
2018 |
rs12794714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12794714 and rs10877012 SNPs were associated with asthma risk.
|
29502202 |
2018 |
rs13228377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that LEP polymorphism (rs13228377) was associated with higher serum leptin levels in asthma and these two variables had high predictive value for asthma risk (P = 0.007, odds ratio 17.5, predictive accuracy 83.9%).
|
30203371 |
2018 |
rs13925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment.
|
29600353 |
2018 |
rs1416580204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of G82S genotypes was significantly different between neutrophilic and non‑neutrophilic asthmatics (P=0.009).
|
29257350 |
2018 |
rs1990760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe associations that may predict ADEs, e.g., acne, high cholesterol, gout, and gallstones with rs738409 (p.I148M) in PNPLA3 and asthma with rs1990760 (p.T946A) in IFIH1.
|
30327483 |
2018 |
rs1999071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the first genome-wide association study (GWAS) conducted in Brazil for asthma, a positive association was found between atopic asthma and a variant (rs1999071), which is located between the DAD1 and OXA1L genes, although neither gene has previously been reported to be associated with asthma or allergies.
|
30032071 |
2018 |
rs20544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment.
|
29600353 |
2018 |
rs2229542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, our results show that the rs2229542 variant associates with asthma and rhinitis, and hampers AKR1B1 protein levels and stability.
|
29726087 |
2018 |
rs2670660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children.
|
29154202 |
2018 |
rs2781666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicated that high arginase activity and IL-13 concentration in the serum and ARG1 rs2781666 G/T genotype might increase the risk of asthma in susceptible population.
|
30381539 |
2018 |
rs28903081
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations of seven XRCC3 genotypes, namely rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539 and rs28903081, with the risk of asthma were investigated among 198 patients with asthma and 453 non-asthma controls by polymerase chain reaction-restriction fragment length polymorphism genotyping methodology.
|
30150425 |
2018 |
rs4559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study for association of STAT6 polymorphisms rs4559 and rs324011 with asthma risk was performed.
|
30511616 |
2018 |