Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs61735175
rs61735175
0.010 GeneticVariation BEFREE The G allele of rs61735175 was positively associated with asthma severity in the additive model (OR 1.72, 95% CI 1.07-2.77) and in the dominant model (OR 1.77, 95% CI 1.09-2.85). 31126515

2019

dbSNP: rs6692977
rs6692977
0.010 GeneticVariation BEFREE Our results showed that the frequencies of the rs6692977 CT genotype and T allele within FCRL5 were significantly higher in asthma with comorbid AR compared to healthy controls (Bonferroni-corrected p (Pc) = 3.75 × 10<sup>-6</sup>; Pc = 0.006, respectively), whereas these of the CC genotype and C allele were significantly lower (Pc = 4.15 × 10<sup>-5</sup>; Pc = 0.006, respectively). 30771554

2019

dbSNP: rs7528684
rs7528684
0.010 GeneticVariation BEFREE The frequencies of the rs7528684 A allele (Pc = 1.80 × 10<sup>-3</sup>) and the rs10489678 G allele (Pc = 0.04) within FCRL3 were higher in asthma with comorbid AR than in controls. 30771554

2019

dbSNP: rs755348141
rs755348141
0.010 GeneticVariation BEFREE Clinical studies report that the population variant Gln27Glu is associated with a differential response to common asthma drugs, such as albuterol, isoproterenol and terbutaline. 31520159

2019

dbSNP: rs7635009
rs7635009
0.010 GeneticVariation BEFREE Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of <i>MYH15</i> and may be functional variants conferring susceptibility to asthma. 30906771

2019

dbSNP: rs766736182
rs766736182
IL7
0.010 GeneticVariation BEFREE This study reveals that SNP rs766736182 of interleukin-7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma. 30239047

2019

dbSNP: rs833069
rs833069
0.010 GeneticVariation BEFREE The ADAM33 rs528557/S2 and the VEGFA rs833069 SNPs were associated with Thai asthmatics, as well as with other populations worldwide. 31586488

2019

dbSNP: rs9288876
rs9288876
0.010 GeneticVariation BEFREE Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of <i>MYH15</i> and may be functional variants conferring susceptibility to asthma. 30906771

2019

dbSNP: rs946261
rs946261
0.010 GeneticVariation BEFREE In the Tsukuba GWAS cohort, the C allele at rs946261 was significantly associated with reduced expression of CHI3L1 mRNA in the lung and with development of asthma (odds ratio (OR) 1.27; P = 0.036). 30940096

2019

dbSNP: rs10877012
rs10877012
0.010 GeneticVariation BEFREE We found that rs12794714 and rs10877012 SNPs were associated with asthma risk. 29502202

2018

dbSNP: rs1135216
rs1135216
0.010 GeneticVariation BEFREE Subgroup analysis by atopic types indicated significant association of TAP1 polymorphism rs1135216 with asthma in the allele, dominant and recessive models and with allergic rhinitis in the recessive model. 29416713

2018

dbSNP: rs11651270
rs11651270
0.010 GeneticVariation BEFREE Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children. 29154202

2018

dbSNP: rs12150220
rs12150220
0.010 GeneticVariation BEFREE Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children. 29154202

2018

dbSNP: rs12794714
rs12794714
0.010 GeneticVariation BEFREE We found that rs12794714 and rs10877012 SNPs were associated with asthma risk. 29502202

2018

dbSNP: rs13228377
rs13228377
LEP
0.010 GeneticVariation BEFREE We observed that LEP polymorphism (rs13228377) was associated with higher serum leptin levels in asthma and these two variables had high predictive value for asthma risk (P = 0.007, odds ratio 17.5, predictive accuracy 83.9%). 30203371

2018

dbSNP: rs13925
rs13925
0.010 GeneticVariation BEFREE The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment. 29600353

2018

dbSNP: rs1416580204
rs1416580204
MOK
0.010 GeneticVariation BEFREE The frequency of G82S genotypes was significantly different between neutrophilic and non‑neutrophilic asthmatics (P=0.009). 29257350

2018

dbSNP: rs1990760
rs1990760
0.010 GeneticVariation BEFREE We describe associations that may predict ADEs, e.g., acne, high cholesterol, gout, and gallstones with rs738409 (p.I148M) in PNPLA3 and asthma with rs1990760 (p.T946A) in IFIH1. 30327483

2018

dbSNP: rs1999071
rs1999071
0.010 GeneticVariation BEFREE In the first genome-wide association study (GWAS) conducted in Brazil for asthma, a positive association was found between atopic asthma and a variant (rs1999071), which is located between the DAD1 and OXA1L genes, although neither gene has previously been reported to be associated with asthma or allergies. 30032071

2018

dbSNP: rs20544
rs20544
0.010 GeneticVariation BEFREE The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment. 29600353

2018

dbSNP: rs2229542
rs2229542
0.010 GeneticVariation BEFREE Taken together, our results show that the rs2229542 variant associates with asthma and rhinitis, and hampers AKR1B1 protein levels and stability. 29726087

2018

dbSNP: rs2670660
rs2670660
0.010 GeneticVariation BEFREE Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children. 29154202

2018

dbSNP: rs2781666
rs2781666
0.010 GeneticVariation BEFREE This study indicated that high arginase activity and IL-13 concentration in the serum and ARG1 rs2781666 G/T genotype might increase the risk of asthma in susceptible population. 30381539

2018

dbSNP: rs28903081
rs28903081
0.010 GeneticVariation BEFREE Associations of seven XRCC3 genotypes, namely rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539 and rs28903081, with the risk of asthma were investigated among 198 patients with asthma and 453 non-asthma controls by polymerase chain reaction-restriction fragment length polymorphism genotyping methodology. 30150425

2018

dbSNP: rs4559
rs4559
0.010 GeneticVariation BEFREE A case-control study for association of STAT6 polymorphisms rs4559 and rs324011 with asthma risk was performed. 30511616

2018