rs7927894
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Subgroup analysis revealed no significant association of rs7927894 with early age of onset of the disease, concomitant asthma and allergic rhinoconjunctivitis, total serum IgE levels and family history of atopy.
|
23557745 |
2013 |
rs7927894
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever.
|
21429916 |
2011 |
rs10197862
|
|
|
0.810 |
GeneticVariation |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
rs13408661
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs2284033
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
rs2786098
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We observed replication of the association of asthma</span> with SNP rs2786098 in the independent series of persons of European ancestry (combined P=9.3x10(-11)).
|
20032318 |
2010 |
rs3117098
|
|
|
0.810 |
GeneticVariation |
BEFREE |
rs3117098 may be the risk factor for asthma in Chinese Zhuang population.
|
31605414 |
2020 |
rs3771166
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
rs3894194
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Besides, linear regression analysis showed that rs3894194 and rs12603332 were also significantly associated with asthma phenotypes such as log10 -transformed immunoglobulin E (IgE) level (IU/ml) and log10 -transformed eosinophil percentage (dominant, P=0.04; additive, P=0.01; recessive, P=0.04; recessive, P=0.03; additive, P=0.02).
|
24649901 |
2014 |
rs404860
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07 × 10(-23)), which is close to rs2070600, a SNP previously reported for association with FEV(1)/FVC in genome-wide association studies for lung function.
|
21804548 |
2011 |
rs4794820
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Moreover, the GA and AA genotypes of rs4794</span>820 were associated with higher logPC(20) values and lower eosinophil percentages than the GG genotype in subjects who had been diagnosed with asthma, or showed bronchial hyperresponsiveness (PC(20)≤16).
|
22732088 |
2012 |
rs6503525
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The present study reports that the polymorphic genomic variant rs3816470 is significantly and independently associated with asthma in the studied population, while the variants, rs6503525 and rs3859192, also indicate a significant association with asthma in this population when family history of the disease is taken as a covariate.
|
26203825 |
2015 |
rs7130588
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
|
21907864 |
2011 |
rs744910
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
rs7775228
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The statistical analysis showed no significant difference for loci rs404860 and rs7775228 between patients with asthma and controls.
|
31605414 |
2020 |
rs907092
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10<sup>-12</sup>) at <i>IKZF3</i> Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as <i>IKZF3</i> (<i>e.g.
|
28461288 |
2017 |
rs9268516
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs9272346
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Of these, a common polymorphism (rs9272346) localizing to within 1 Kb of HLA-DQA1 (chromosome 6p21.3) was associated with asthma in adults (P-value = 2.2E-08) with consistent evidence in the more heterogeneous group of adults and children (P-value = 1.0E-04).
|
23181788 |
2012 |
rs9273349
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
rs987870
|
|
|
0.810 |
GeneticVariation |
BEFREE |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
rs992969
|
|
|
0.810 |
GeneticVariation |
BEFREE |
For ORMDL3-GSDMB region, rs8067378 (G allele protective against asthma) was correlated with decreased expression of GSDMB in BEC and BAL (P = 1.3 × 10(-4) and 0.04) but not ORMDL3. rs992969 in the promoter region of IL33 (A allele associated with higher eosinophil counts and risk for asthma) was correlated with increased expression of IL33 in BEC (P = 1.3 × 10(-6) ) but not in BAL.
|
26119467 |
2015 |
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients.
|
28273659 |
2017 |
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear.
|
22286212 |
2012 |
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
ICSNPathway analysis identified four candidate causal SNPs, four genes, and 21 candidate causal pathways, which in total provided four hypothetical biologic mechanisms: (1) rs7192 (nonsynonymous coding) to HLA-DRA to 21 pathways, such as, the role of eosinophils in the chemokine network of allergy, Th1/Th2 differentiation, and asthma (nominal p ≤ 0.001, FDR p ≤ 0.01); (2) rs20541 (nonsynonymous coding) to IL13 to asthma and cytokines and inflammatory response (nominal p<0.001, FDR p ≤ 0.008); (3) rs1058808 (frameshift coding) to ERBB2 to transmembrane receptor activity (nominal p=0.001, FDR p=0.01); (4) rs17350764 (nonsynonymous coding (deleterious)) to OR52J3 to transmembrane receptor activity (nominal p=0.001, FDR p=0.01).
|
23200760 |
2013 |