The rs10399931 CT/TT genotype increased the risk of asthma under the dominant model (<i>P</i> = 0.031, OR = 1.428, 95% CI, 1.033-1.974), while the CT genotype showed the same tendency under the heterozygous model (<i>P</i> = 0.003, OR = 1.680, 95% CI, 1.186-2.380).
Our findings suggest that the CHI3L1 polymorphisms rs1538372 and rs10399931 can be used as genetic markers for predicting asthma risk in the Taiwanese population.
Interestingly, it has been reported that rs10399931 (-329 G/A) of CHI3LI contributes to the inter-individual plasma YKL-40 levels in patients with sarcoidosis, and that rs4950928 (-131 C/G) is a susceptibility polymorphism for asthma and a decline in lung function.