|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of this meta-analysis suggested that the IL4RA I50V and Q551R polymorphisms may be risk factors for developing asthma.
|
23922687 |
2013 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms rs2243250 and rs2070874 of IL-4 and rs1801275 and rs1805011 of IL4R were associated with asthma.
|
23924473 |
2013 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found an association between atopic bronchial asthma and the SNPs Gln576Arg in IL4RA and -33C>T in IL4.
|
22533235 |
2012 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL4RA Q551R SNP is associated with nonatopic asthma in Slovenian children.
|
20517665 |
2010 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined analysis of two IL4RA single nucleotide polymorphisms (SNPs) (I50V and Q551R) showed an association with asthma: IL4RA V50/Q551 was associated with risk (OR = 2.48, p = 0.007) whereas the IL4RA V50R551 haplotype was associated with protection (OR = 0.31, p = 0.003).
|
18849614 |
2009 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4R alpha-dependent signaling.
|
19770271 |
2009 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We sought to determine the average risk of asthma associated with the I50V and Q551R IL4R variants based on the results of case-control studies reported in the literature.
|
17586032 |
2007 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to investigate the association of the polymorphisms for IL-4 (C-589T), IL-4R alpha (Gln576Arg), TNF-alpha (G-308A) and LT-alpha (A252G) genes as candidates and asthma in adult Hong Kong Chinese population.
|
17536219 |
2007 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether Ile50Val and Q576R polymorphisms of IL-4 receptor alpha chain gene were associated with asthma and higher level of total IgE in Chinese, Malay and Indian populations.
|
16757160 |
2007 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in the interleukin-4 (C-590T), interleukin-4 receptor (ile50val and gln576arg), and interleukin-13 (arg130gln) genes have been described as susceptibility alleles for asthma.
|
17284225 |
2007 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For the Arg551Gln polymorphism, the combined genotype frequency of the Arg/Gln heterozygote and the Arg/Arg homozygote was significantly higher in atopic asthmatics (27.6%) than in healthy children (16.0%) (odds ratio (OR) = 1.97, 95% CI (confidence interval) = 1.07-3.71).
|
15298559 |
2004 |
|
rs1801275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) leading to the protein exchanges I50V, E375A, C406R, S478P and Q551R in the IL-4 receptor alpha were examined for allele sharing in sibs with asthma.
|
12047364 |
2002 |