A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250</span>, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determiningasthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05).
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).