The presence of allergic rhinitis in asthmatic children strengthened the association of the rs11466749 GG genotype with asthma (p = 0.001), and rs2289276 was significantly associated with lower FEV1 levels in asthmatics without allergic rhinitis (p = 0.003).
We found that the promoter polymorphisms rs3806933 and rs2289276 were significantly associated with disease susceptibility in both childhood atopic and adult asthma.
Two SNPs in TSLP (rs1837253 and rs2289</span>276) were significantly associated with a reduced risk of a</span>sthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively).