|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Two coding variants (rs2305480 and rs11078928) of the gasdermin B (GSDMB) gene in the 17q21 locus were associated with lower asthma risk in both GERA (odds ratio, 0.92; P = 1.01 × 10<sup>-6</sup>) and EVE (odds ratio, 0.85; joint P<sub>EVE</sub> = 1.31 × 10<sup>-13</sup>).
|
29330013 |
2018 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Analyses of asthma phenotypes found no association with atopy or lung function, but rs2305480 and rs8066582 were associated with childhood asthma and rs9916279 was associated with asthma in smokers.
|
27163155 |
2016 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96).
|
26534891 |
2016 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
For two of these six loci (rs2305480 and rs8067378), there was evidence of association with asthma, and there was a weak association of asthma with rs8069176.
|
22370936 |
2012 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
rs2305480
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs2305480
|
|
G |
0.860 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Eleven SNPs were significantly associated with asthma (P<0.01), of which three (rs8069176, rs2305480, and rs4795400) were strongly associated (P<0.001).
|
18923164 |
2008 |