|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
<b>Results:</b> A SNP (rs4950928) in the <i>CHI3L1</i> promoter was associated with elevated plasma YKL-40 levels (<i>p</i> = .02), asthma (<i>p</i> = .042) and lung function (<i>p</i> = .029 to .002) in this Chinese population.
|
31295039 |
2019 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
There was no significant association between the <i>CHI3L1</i> rs4950928 polymorphism and the risk of asthma in the meta-analysis.
|
30988078 |
2019 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The G allele of CHI3L1 rs4950928 might be a protective factor against the development of asthma.
|
29233108 |
2017 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Plasma YKL-40 levels were examined in relation to CHI3L1 rs4950928 genotype and clinical characteristics including Asthma Predictive Index, medication use, time spent with respiratory symptoms, atopic status, and blood leukocytes.
|
27732738 |
2017 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Serum chitotriosidase (CHIT1) activity and YKL-40 (CHI3L1) levels, as well as the CHIT1 rs3831317 and CHI3L1 rs4950928 genotypes, were examined in subsets of patients with mild to moderate asthma (n = 76), severe asthma (n = 93), and COPD (n = 64) taking part in the European multicenter BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) study.
|
26372680 |
2016 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In contrast to the promoter SNP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function, and YKL-40 expression in the blood and airway.
|
25592985 |
2015 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs.
|
21530869 |
2011 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In contrast to previous studies, the rs4950928 G allele, and not the C allele, was found to be associated with asthma.
|
19568425 |
2009 |
|
rs4950928
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Interestingly, it has been reported that rs10399931 (-329 G/A) of CHI3LI contributes to the inter-individual plasma YKL-40 levels in patients with sarcoidosis, and that rs4950928 (-131 C/G) is a susceptibility polymorphism for asthma and a decline in lung function.
|
19421404 |
2009 |