|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Individuals with CT and GG genotype of C1112T in IL 13 and Ile50Val in IL 4 R were at twice the risk for the development of asthma compared to individuals with both non-risk genotypes.
|
25402004 |
2015 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The results of this meta-analysis suggested that the IL4RA I50V and Q551R polymorphisms may be risk factors for developing asthma.
|
23922687 |
2013 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The combined analysis of two IL4RA single nucleotide polymorphisms (SNPs) (I50V and Q551R) showed an association with asthma: IL4RA V50/Q551 was associated with risk (OR = 2.48, p = 0.007) whereas the IL4RA V50R551 haplotype was associated with protection (OR = 0.31, p = 0.003).
|
18849614 |
2009 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To verify the association of transforming growth factor-beta1(TGF-beta1) (C-509T and T869C), CD14 (C-159T), IL-4 (C-590T), IL-4R (ILe50Val) and ADAM33 (S_2) gene polymorphisms with asthma severity in a sample of patients with mild, moderate and severe persistent atopic asthma.
|
18425216 |
2008 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
I50V variants were not significantly associated with asthma.
|
17586032 |
2007 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To determine whether Ile50Val and Q576R polymorphisms of IL-4 receptor alpha chain gene were associated with asthma and higher level of total IgE in Chinese, Malay and Indian populations.
|
16757160 |
2007 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Polymorphisms in the interleukin-4 (C-590T), interleukin-4 receptor (ile50val and gln576arg), and interleukin-13 (arg130gln) genes have been described as susceptibility alleles for asthma.
|
17284225 |
2007 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A significant interaction was found between R130Q in the IL-13 gene (IL13) and I50V in the IL-4 receptor alpha gene (IL4RA) on the risk of asthma, with a cross-validation consistency of 10 of 10 and a prediction error of 33.7% (P = .014).
|
16387595 |
2006 |
|
rs555743307
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our findings indicate that the Ile50Val polymorphism of IL4R does not play a substantial role in genetic predisposition for the etiology of atopy or asthma in this Japanese population.
|
10390422 |
1999 |