|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We further found that the haplotype CT for IL-17F (rs763780/rs2397084) was associated with an increased susceptibility of asthma, but this association did not survive after FDR correction.
|
30036556 |
2018 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results revealed that, in an Asian population, IL-17 rs763780, rs2275913, and rs8193036 SNPs may be associated with asthma susceptibility, and GA genotype in rs2275913 and TT genotype in rs8193036 of IL-17 may contribute to increased risk of asthma in Asians.
|
26954344 |
2016 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We investigated the possible association among asthma and IL-17A -197G/A (rs2275913), IL-17F 7488A/G (rs763780) and IL-17F 7383A/G (rs2397084).
|
24393079 |
2014 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In atopic patients with asthma, prebronchodilator baseline FEV1/FVC values showed a significant association with the H161R variant.
|
24829928 |
2014 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We also found that the haplotype with minor alleles for rs763780 was associated with an increased risk of asthma (adjusted OR, 1.62; 95% CI, 1.11-2.35; P = .0115).
|
22812194 |
2012 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We investigated the possible association between asthma and 5 single-nucleotide polymorphisms (SNPs) in the interleukin 17 (IL17) gene--rs17880588 (G/A) and rs17878530 (C/T) in IL17A and rs763780 (T/C), rs11465553 (T/C), and rs2397084 (G/A) in IL17F--and compared levels of the proteins IL17A and IL17F in asthma patients with those of controls.
|
22312940 |
2011 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Given that asthma and COPD are complex diseases involving a number of genetic and environmental factors, the genetic impact of IL-17F H161R with regard to the development of chronic airway inflammation likely varies among individuals with different genetic backgrounds and environmental exposures.
|
16961709 |
2006 |
|
rs763780
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The current findings indicate that the IL-17F H161R variant influences the risk of asthma and is a natural IL-17F antagonist, suggesting a potential role for IL-17F in the etiology of asthma.
|
16630936 |
2006 |