Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs142117234
rs142117234
IL4
A 0.700 GeneticVariation GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474

2019

dbSNP: rs2243250
rs2243250
IL4
0.060 GeneticVariation BEFREE A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250</span>, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determining asthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05). 26613553

2016

dbSNP: rs2243250
rs2243250
IL4
0.060 GeneticVariation BEFREE IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05). 27819719

2016

dbSNP: rs2243250
rs2243250
IL4
0.060 GeneticVariation BEFREE rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis. 23654077

2013

dbSNP: rs2243250
rs2243250
IL4
0.060 GeneticVariation BEFREE Polymorphisms rs2243250 and rs2070874 of IL-4 and rs1801275 and rs1805011 of IL4R were associated with asthma. 23924473

2013

dbSNP: rs2243250
rs2243250
IL4
0.060 GeneticVariation BEFREE No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma. 23964553

2013

dbSNP: rs2243250
rs2243250
IL4
0.060 GeneticVariation BEFREE Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma. 22652416

2012

dbSNP: rs2070874
rs2070874
IL4
0.050 GeneticVariation BEFREE IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05). 27819719

2016

dbSNP: rs2070874
rs2070874
IL4
0.050 GeneticVariation BEFREE Individuals who carried the C allele for rs2070874 of the IL4 gene demonstrated increased asthma risk compared to TT homozygotes. 23924473

2013

dbSNP: rs2070874
rs2070874
IL4
0.050 GeneticVariation BEFREE A total of 214 atopic patients (108 with asthma and 106 with allergic rhinitis) and 120 healthy controls from Pakistan were genotyped for IL-4 SNPs C-589T (rs2243250), T+2979G (rs2227284), and C-33T (rs2070874) using restriction fragment length polymorphism-polymerase chain reaction. 23654077

2013

dbSNP: rs2070874
rs2070874
IL4
0.050 GeneticVariation BEFREE No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma. 23964553

2013

dbSNP: rs2070874
rs2070874
IL4
0.050 GeneticVariation BEFREE In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population. 22053598

2011

dbSNP: rs2227284
rs2227284
IL4
0.030 GeneticVariation BEFREE We found a significant association of IL2 rs6534349 polymorphism with increased asthma risk (heterozygotes, P=.029; homozygous variants; P=.013) and of IL4 rs2227284 polymorphism with reduced asthma risk (heterozygotes, P=.026; homozygous variants; P=.001). 25747600

2015

dbSNP: rs2227284
rs2227284
IL4
0.030 GeneticVariation BEFREE rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis. 23654077

2013

dbSNP: rs2227284
rs2227284
IL4
0.030 GeneticVariation BEFREE No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma. 23964553

2013

dbSNP: rs79908535
rs79908535
0.020 GeneticVariation BEFREE The present findings suggest that SJS/TEN is different from allergic diseases such as atopy and asthma because the ratio of each allele in the IL-13 SNP Arg110Gln was the opposite of the ratio in those diseases. 18263811

2008

dbSNP: rs79908535
rs79908535
0.020 GeneticVariation BEFREE A novel variant of human IL-13, Gln110Arg, on chromosome 5q31, associated with asthma rather than IgE levels in case-control populations from Britain and Japan [peak odds ratio (OR) = 2.31, 95% CI 1.33-4.00]; the variant also predicted asthma and higher serum IL-13 levels in a general, Japanese paediatric population. 10699178

2000

dbSNP: rs2243290
rs2243290
0.010 GeneticVariation BEFREE Ours is the first study in a non-Western population to show that the IL4 SNP rs2243290 was significantly associated with the risk of asthma. 23964553

2013

dbSNP: rs1329751852
rs1329751852
0.010 GeneticVariation BEFREE A SNP (rs2228137) (R62W) in FCER2 has been linked with severe exacerbations in asthmatics. 22059556

2011

dbSNP: rs1196477957
rs1196477957
0.010 GeneticVariation BEFREE After stratification by atopic status, the heterozygous AG genotype of LT-alpha (A252G) was found to increase risk of asthma in atopic population [odds ratio (OR) = 2.00, 95% CI 1.09-3.67, p = 0.024]. 17536219

2007

dbSNP: rs4986964
rs4986964
IL4
0.010 GeneticVariation BEFREE Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy. 15372320

2004