rs142117234
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
rs2243250
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250</span>, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determining asthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05).
|
26613553 |
2016 |
rs2243250
|
|
|
0.060 |
GeneticVariation |
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
rs2243250
|
|
|
0.060 |
GeneticVariation |
BEFREE |
rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis.
|
23654077 |
2013 |
rs2243250
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Polymorphisms rs2243250 and rs2070874 of IL-4 and rs1801275 and rs1805011 of IL4R were associated with asthma.
|
23924473 |
2013 |
rs2243250
|
|
|
0.060 |
GeneticVariation |
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
rs2243250
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma.
|
22652416 |
2012 |
rs2070874
|
|
|
0.050 |
GeneticVariation |
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
rs2070874
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Individuals who carried the C allele for rs2070874 of the IL4 gene demonstrated increased asthma risk compared to TT homozygotes.
|
23924473 |
2013 |
rs2070874
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A total of 214 atopic patients (108 with asthma and 106 with allergic rhinitis) and 120 healthy controls from Pakistan were genotyped for IL-4 SNPs C-589T (rs2243250), T+2979G (rs2227284), and C-33T (rs2070874) using restriction fragment length polymorphism-polymerase chain reaction.
|
23654077 |
2013 |
rs2070874
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
rs2070874
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
rs2227284
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found a significant association of IL2 rs6534349 polymorphism with increased asthma risk (heterozygotes, P=.029; homozygous variants; P=.013) and of IL4 rs2227284 polymorphism with reduced asthma risk (heterozygotes, P=.026; homozygous variants; P=.001).
|
25747600 |
2015 |
rs2227284
|
|
|
0.030 |
GeneticVariation |
BEFREE |
rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis.
|
23654077 |
2013 |
rs2227284
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
rs79908535
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present findings suggest that SJS/TEN is different from allergic diseases such as atopy and asthma because the ratio of each allele in the IL-13 SNP Arg110Gln was the opposite of the ratio in those diseases.
|
18263811 |
2008 |
rs79908535
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A novel variant of human IL-13, Gln110Arg, on chromosome 5q31, associated with asthma rather than IgE levels in case-control populations from Britain and Japan [peak odds ratio (OR) = 2.31, 95% CI 1.33-4.00]; the variant also predicted asthma and higher serum IL-13 levels in a general, Japanese paediatric population.
|
10699178 |
2000 |
rs2243290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Ours is the first study in a non-Western population to show that the IL4 SNP rs2243290 was significantly associated with the risk of asthma.
|
23964553 |
2013 |
rs1329751852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A SNP (rs2228137) (R62W) in FCER2 has been linked with severe exacerbations in asthmatics.
|
22059556 |
2011 |
rs1196477957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by atopic status, the heterozygous AG genotype of LT-alpha (A252G) was found to increase risk of asthma in atopic population [odds ratio (OR) = 2.00, 95% CI 1.09-3.67, p = 0.024].
|
17536219 |
2007 |
rs4986964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy.
|
15372320 |
2004 |